Study Detail

TitleCanonical Wnt signaling negatively modulates T regulatory cell function
Study TypeOther
Abstract Foxp3 is crucial for both the development and function of regulatory T cells (Treg),however the post-translational mechanisms regulating Foxp3 transcriptional output remain poorly defined. Here, we demonstrate that TCF1 and Foxp3 interact in the nucleus of Treg, and that active Wnt-signaling disrupt .. [more]
Center NameGEO