Study Detail

TitleRole of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation [ChIP-Seq]
Study TypeOther
Abstract Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known .. [more]
Center NameGEO