Study: JGAS00000000004

Identifier

AccessionJGAS00000000004

Description

TitleGenomic and Genetic Analysis of Brain Tumors and Analysis of Their Clinicopathological Significance
AbstractThe treatment outcome of glioma patients remains disappointing, and more studies are needed to improve therapeutic strategies. In particular, it is crucial to understand the mechanisms underlying resistance to treatment and malignant transformation, as well as the intratumoral heterogeneity and interaction of tumor cells and host immunity. Recent advances in omics analysis techniques, such as next-generation sequencing (NGS), have enabled us to obtain omics data more easily and accelerated our ability to integrate this information and precisely characterize cases. In our project, we have already collected more than 100 pairs of human glioma/normal tissue samples, of which some are multiple specimens collected from initial and recurrent tumors, and some include multiple specimens collected from different regions within a single tumor. We used our in-house algorithms, composed of alignment and variant calling programs, to analyze omics data from multiple platforms, such as whole-exome sequencing (WES), RNA sequencing (RNA-seq), and methylation array, with our original cohort of glioma patients. Using several informatics tools, the information about genetic and epigenetic status and expression signatures were analyzed. Those data are expected to provide key information for investigating the mechanisms discussed above. Through this project, we hope to improve strategies for personalized therapy based on comprehensive omics data.
Study Type 1
Study TypeTumor vs. Matched-Normal
Study Type 2
Study TypeExome Sequencing
Study Type 3
Study TypeTranscriptome Sequencing
Study Type 4
Study TypeOther
New Study TypeDNA methylation array

Grant

TitleP-DIRECT: Project for Development of Innovative Research on Cancer Therapeutics
AgencyMinistry of Education, Culture, Sports, Science and Technology (MEXT)
Grant ID

Publication

Publication 1
PubMed ID24336570
Publication Statuspublished
DB TypePUBMED
Publication 2
PubMed ID28270234
Publication Statuspublished
DB TypePUBMED

Study Attribute

NBDC Numberhum0006
Submitting organizationDepartment of Neurosurgery, The University of Tokyo
Principal InvestigatorNobuhito Saito
Dataset
Accession Title Dataset type Data objects Policy
JGAD00000000004 Exomes of 23 low-grade gliomas to their recurrences resected up to 11 years later. Random exome sequencing 23 JGAP00000000004
JGAD00000000106 Exome of 32 oligodendroglioma and matched-normal from 16 patients Exome sequencing 96 JGAP00000000004
JGAD00000000107 RNAseq of 27 oligodendroglioma Transcriptome profiling by high-throughput sequencing 54 JGAP00000000004
JGAD00000000108 DNA-methylation array of 30 oligodendroglioma 0 JGAP00000000004