Study: JGAS00000000037

Identifier

AccessionJGAS00000000037

Description

TitleDevelopment of molecular targeted therapy for small cell lung cancer by comprehensive genome analysis
AbstractAims: Identifying new therapeutic targets of small cell lung cancer (SCLC), genome-wide mutation analysis has been performed. Methods: Genomic DNA was extracted from formalin-fixed or methanol-fixed tissue samples. 71 Mb of DNA fragments containing whole coding exons were concentrated using SureSelect Human All Exon V4+UTRs Kit (Agilent Technologies) followed by 100-bp paired end sequencing by HiSeq 2000 (Illumina). Participants/Materials: 51 of 1042 cases of pathologically diagnosed small seen lung cancer that were registered to National Cancer Hospital East Lung Cancer Database in 1992-2012, and which surgically resected or biopsy samples were suitable for DNA extraction for further analyses.
Study Type 1
Study TypeCase Set
Study Type 2
Study TypeTumor vs. Matched-Normal
Study Type 3
Study TypeExome Sequencing

Grant

Grant 1
TitleExploring therapeutic targets and investigating molecular carcinogenesis of small cell lung cancer by comprehensive genome analysis
AgencyGrants-in-Aid for Scientific Research, Ministry of Education, Culture, Sports , Science and Technology (KAKENHI)
Grant ID24300346
Grant 2
TitleDevelopment of molecular targeted therapy for large cell neuroendocrine carcinoma by targeting genome sequencing
AgencyGrants-in-Aid for Scientific Research, Ministry of Education, Culture, Sports , Science and Technology (KAKENHI)
Grant ID26870876
Grant 3
TitleDevelopment of the biostatistics and bioinformatics platforms for cancer research
AgencyNational Cancer Center (NCC)
Grant ID23

Publication

PubMed ID25122428
Publication Statuspublished
DB TypePUBMED

Study Attribute

NBDC Numberhum0034
Registration date2014-01-01
Submitting organizationNational Cancer Center
Dataset
Accession Title Dataset type Data objects Policy
JGAD00000000037 Exome sequencing of SCLC 51 cases Random exome sequencing 102 JGAP00000000004