Study: JGAS00000000061

Identifier

AccessionJGAS00000000061

Description

TitleGeriatric Oncology Database of genotypes and methylation, gene expression, clinical data, and survey results on psychosocial and physical conditions in Japanese elderly cancer patients to establish truly effective treatment strategy
AbstractOwing to the advent of super-aged society, cancer mortality in Japan is forecasted to become an all-time high. The management of elderly patients with cancer is a serious health issue and the need for specific care guidelines for this population is critical in Japan. The significant individual differences in comorbidity, physical and mental functioning, and social problems among aging individuals are obstacles to the progress. The response to cancer treatment varies significantly among patients, even in the same stage of the same type of cancer. Older aged patients are still less likely to be offered participation in clinical trials, thus the number of clinical evidences is limited. The molecular mechanisms regulating the physiological process of ageing and senescence, and cancer are far from understood. To establish a truly effective treatment algorithm, we attempted to develop a geriatric oncology database for genotypes and methylation, gene expression, clinical data, and survey results on psychosocial and physical conditions in Japanese elderly cancer patients in this retrospective study. The genomic analysis was performed in 62, 106, and 173 cases, respectively for gastric, colon and lung cancers. The clinical data and survey results on psychosocial and physical conditions were collected from 166, 313, and 344 patients respectively for gastric, colon and lung cancers, and also collected from 357, 49, and 300 benign cases respectively for cardiovascular disorder, respiratory dysfunction, diabetes and nephropathy as the analysis control.
Study Type 1
Study TypeCase Set
Study Type 2
Study TypeControl Set

Study Attribute

NBDC Numberhum0064
Registration date2016-07-12
Submitting organizationGunma University
Principal InvestigatorMasahiko Nishiyama
Molecular Data TypeGene expression (cDNA microarray)
PlatformG2565BA
VendorAgilent
Comment
Molecular Data TypeGene expression (qPCR)
PlatformLightCycler480
VendorRoche
Comment
Molecular Data TypeGenotyping
PlatformLightCycler480
VendorRoche
Comment
Molecular Data TypeGenotyping
PlatformGenetic Analyzer 3130
VendorABI
Comment
Primary PhenotypeCancer
PhenotypeCardiovascular disorder
PhenotypeRespiratory dysfunction
PhenotypeNephropathy
PhenotypeDiabetes
Study Inclusion/Exclusion CriteriaCancer case 1) Patients with definite diagnosis of colorectal, gastric, and lung cancer. 2) Patients who had received cancer treatment between September 2002 to June 2006. 3) Patients‚Č•40 years old. 4) Patients with claer records of age, gender, stage, prognosis, and therapeutic response. 5) Patients who agreed enroll to this research project with written informed consent in case of genomic analysys. Benigh case (as the analysis control) 1) Patients with definite diagnosis of cardiovascular disorder, respiratory dysfunction, diabetes and nephropathy. 2) Patients who had no histrory of cancer. And patinets with cancer who achieved complete remission before September 2002. 3) Patients who had received treatments for cardiovascular disorder, respiratory dysfunction, diabetes or nephropathy between September 2002 to June 2006. 4) Patients >= 40 years old. 5) Patients with claer records of age, gender, stage, prognosis, and therapeutic response.
Dataset
Accession Title Dataset type Data objects Policy
JGAD00000000061 Clinic, genetic and survey dataset Study summary information 0 JGAP00000000001