Study: JGAS00000000062

Identifier

AccessionJGAS00000000062

Description

TitleIdentification of new molecular targets with profiling of malignant mesothelioma
AbstractAims: Malignant mesothelioma which is associated with asbestos exposure is highly aggressive and refractory to conventional therapeutic modalities. The aim of this study is identification of new targets for molecular target therapy by next generation sequencing and application of the genomic data to new diagnostic and therapeutic strategies for malignant mesothelioma patients. Methods: We extracted genomic DNAs from surgical specimens or established mesothelioma cell lines from Japanese malignant mesothelioma patients. We also extracted control DNAs from peripheral blood of the same patients. We performed whole exome sequencing using these DNAs.
Study Type 1
Study TypeExome Sequencing
Study Type 2
Study TypeTumor vs. Matched-Normal

Grant

Grant 1
TitleIdentification of new molecular targets with profiling of malignant mesothelioma / Development of therapeutic modalities against intractable cancers via identification of new therapeutic targets with molecular profiling / P-DIRECT: Project for Development of Innovative Research on Cancer Therapeutics
AgencyMinistry of Education, Culture, Sports, Science and Technology (MEXT)
Grant ID
Grant 2
TitleIdentification of new molecular targets with profiling of malignant mesothelioma / Development of therapeutic modalities against intractable cancers via identification of new therapeutic targets with molecular profiling / P-DIRECT: Project for Development of Innovative Research on Cancer Therapeutics
AgencyJapan Agency for Medical Research and Development (AMED)
Grant ID

Study Link

URL Linkhttp://www.pref.aichi.jp/cancer-center/english/ri/01division/03molecular/index.html

Study Attribute

NBDC Numberhum0053
Registration date2016-07-08
Submitting organizationHyogo College of Medicine, Division of Respiratory Medicine
Principal InvestigatorTakashi Nakano
Molecular Data TypeExome sequencing
PlatformHiSeq 2000
VendorIllumina
Comment
Primary PhenotypeMalignant mesothelioma
Disease TypeNeoplasms
Cancer TypeMesothelioma
Dataset
Accession Title Dataset type Data objects Policy
JGAD00000000062 Exome analysis of 38 Japanese malignant mesothelioma patients Exome sequencing 76 JGAP00000000004