Study: JGAS00000000070

Identifier

AccessionJGAS00000000070

Description

TitleCAGE analysis for non-small cell lung carcinoma
AbstractTargeted therapies based on the molecular and histological features of cancer types are becoming standard practice. The most effective regimen in lung cancers is different between squamous cell carcinoma (SCC) and adenocarcinoma (AD). Therefore a precise diagnosis is crucial, but this has been difficult, particularly for poorly differentiated SCC (PDSCC) and AD without a lepidic growth component (non-lepidic AD). Biomarkers enabling a precise diagnosis are therefore urgently needed. To achieve this goal, we performed CAGE (Cap Analysis of Gene Expression) to quantify promoter activities on 97 frozen tissues from surgically resected lung cancers (22 SCC and 75 AD). The result was followed up by by immunohistochemical analysis (IHC) in an independent group.
Study Type
Study TypeTranscriptome Sequencing

Grant

Grant 1
TitleGrant-in-Aid for Scientific Research (C )
AgencyMinistry of Education, Culture, Sports, Science and Technology (MEXT)
Grant ID
Grant 2
TitleResearch Grant for RIKEN Omics Science Center
AgencyMinistry of Education, Culture, Sports, Science and Technology (MEXT)
Grant ID
Grant 3
TitleResearch Grant to RIKEN Preventive Medicine and Diagnosis Innovation Program
AgencyMinistry of Education, Culture, Sports, Science and Technology (MEXT)
Grant ID

Study Attribute

NBDC Numberhum0083
Registration date2016-09-16
Submitting organizationRIKEN Preventive Medicine and Diagnosis Innovation Program
Principal InvestigatorYoshihide Hayashizaki
Molecular Data TypeTranscriptome (Cap Analysis Of Gene Expression)
PlatformHiSeq2500
VendorIllumina
Comment
Primary PhenotypeNon-small cell lung carcinoma
Disease TypeRespiratory Tract Diseases
Dataset
Accession Title Dataset type Data objects Policy
JGAD00000000070 CAGE analysis for non-small cell lung carcinoma Transcriptome profiling by high-throughput sequencing 97 JGAP00000000001