Study: JGAS00000000085




TitleExpression quantitative trait loci analysis using human immune cells in a Japanese population
Abstract<html>Recent evidence suggests that a substantial portion of complex disease risk alleles modify gene expression in a cell-specific manner. Therefore, it is reasonable to expect that cell-specific expression quantitative trait loci (eQTL) analysis can identify the candidate causal mechanisms of complex diseases (an eQTL is a variant whose polymorphism affects gene expression). We fractionated peripheral blood from 105 healthy Japanese volunteers into five major immune cell subsets (CD4<sup>+</sup> T cells, CD8<sup>+</sup> T cells, B cells, NK cells, and monocytes). We quantified gene and exon expression by RNA sequencing, and tested associations with neighboring common variants (MAF ≥ 0.05).</html>
Study Type
Study TypeOther
New Study TypeExpression quantitative trait loci analysis

Study Attribute

NBDC Numberkyamamoto-0001
Registration date2017-02-03
Submitting organizationRIKEN Center for Integrative Medical Sciences
Principal InvestigatorKazuyoshi Ishigaki
Molecular Data TypeRNA-sequencing
PlatformTruSeq Stranded mRNA Library Prep Kits, Hiseq 2500
Primary Phenotypecomplex disease
Accession Title Dataset type Data objects Policy
JGAD00000000085 FPKM 0 JGAP00000000001