Study: JGAS00000000103

Identifier

AccessionJGAS00000000103

Description

TitleGlobal Architecture of anti-Tumor B-Cell Immunity against Gastric Cancer
AbstractRecent successes in tumor immunotherapies have warranted the importance of tumor immunity. Compared to the T-cell immunity, B-cell immune system in cancer is largely elusive. Here we immunogenetically profiled tumor-infiltrating B-cell and T-cell repertoires for exome- characterized diffuse-type gastric carcinoma (DGC), which is remarkable for its B-cell infiltrations, unraveling previously un-defined architectures of B-cell immunity and its interplays with T-cell immunity in cancer. We also performed transcriptome analysis to enumerate the proportions of tumor-infiltrating immune cells in the gastric cancer environment .
Study Type 1
Study TypeOther
New Study TypeTranscriptome sequencing (Tumor only)
Study Type 2
Study TypeOther
New Study TypeRepertoire sequencing (Tumor vs. Matched-Normal)

Grant

Grant 1
TitleKAKENHI Grant-in-Aid for Young Scientists (A)
AgencyJapan Society for the Promotion of Science (JSPS)
Grant ID26710009
Grant 2
TitlePractical Research for Innovative Cancer Control
AgencyJapan Agency for Medical Research and Development (AMED)
Grant ID15655817
Grant 3
TitleBasic Science and Platform Technology Program for Innovative Biological Medicine
AgencyJapan Agency for Medical Research and Development (AMED)
Grant ID14014019

Publication

DOI ID10.1016/j.celrep.2017.07.016
Publication Statuspublished
DB TypeDOI

Study Attribute

NBDC Numberhum0111
Registration date2017-05-19
Submitting organizationDepartment of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University
Principal InvestigatorShumpei Ishikawa
Molecular Data TypeAmplicon Sequencing of T/B cell antigen receptors
PlatformMiSeq
VendorIllumina
Comment
Molecular Data TypeWhole Transcriptome Sequencing
PlatformHiSeq 2000
VendorIllumina
Comment
Primary PhenotypeStomach cancer
Dataset
Accession Title Dataset type Data objects Policy
JGAD00000000104 Amplicon Sequencing of IgVH, IgVK/L, TCRalpha, TCRbeta Amplicon sequencing 240 JGAP00000000001
JGAD00000000105 Transcriptome sequencing Transcriptome profiling by high-throughput sequencing 0 JGAP00000000001