Study: JGAS00000000108

Identifier

AccessionJGAS00000000108

Description

TitleGenomic DNA analysis for malignant mesothelioma from the patients of Japan and USA.
AbstractMalignant mesotheliomas (MMs) are highly aggressive adult malignancies and exposure to asbestos is the major factor involved in MM pathogenesis. It is desirable for a better understanding of the molecular pathogenesis of MM will lead to more specific and effective targeted therapies. In addition it is reported that germline mutation in a specific gene (ex. BAP1) associates familial MMs, and new candidate markers to determine a subject’s predisposition to MM and for early detection need to be identified. Analysis of genomic DNA from MM tumors and reference peripheral blood from Japan and USA are ongoing to find the common genomic characters beyond race.
Study Type
Study TypeTumor vs. Matched-Normal

Grant

Grant 1
TitleAnalysis of genome rearrangements in chr3p21 of cancers caused by environmental carcinogens, including malignant mesothelioma.
AgencyMinistry of Education, Culture, Sports, Science and Technology (MEXT)
Grant ID0
Grant 2
TitleFinding of the predisposition genes to malignant mesothelioma.
AgencyMinistry of Education, Culture, Sports, Science and Technology (MEXT)
Grant ID0

Publication

PubMed ID27834213
Publication Statuspublished
DB TypePUBMED

Study Attribute

NBDC Numberhum0085
Registration date2016-12-05
Submitting organizationDepartment of Genetics, Hyogo College of Medicine
Principal InvestigatorMasaki Ohmuraya
Molecular Data TypeTarget Capture Sequencing
PlatformMiSeq
VendorIllumina
Comment
Molecular Data TypeWhole Genome Sequencing
PlatformHiSeq X Ten
VendorIllumina
Comment
Primary PhenotypeCancer
PhenotypeMalignant mesothelioma
diseasemalignant mesothelioma
chromosomechr3p21
Dataset
Accession Title Dataset type Data objects Policy
JGAD00000000116 Targeted NGS of malignant mesothelioma and WGS of malignant mesothelioma Whole genome sequencing 135 JGAP00000000008