Study: JGAS00000000124

Identifier

AccessionJGAS00000000124

Description

TitleCAGE analysis for endometrial carcinoma
AbstractFor endometrial cancer patients, lymphadenectomy is recommended to exclude rarely metastasized cancer cells. This procedure is performed even in patients with low risk of recurrence despite the risk of complications such as lymphedema. A method to accurately identify cases with no lymph node metastases (LN-) before lymphadenectomy is therefore highly required. We approached this clinical problem by examining primary lesions of endometrial cancers with CAGE (Cap Analysis Gene Expression), which quantifies promoter-level expression across the genome. Fourteen profiles delineated distinct transcriptional networks between LN + and LN- cases, within those classified as having the low or intermediate risk of recurrence.
Study Type
Study TypeTranscriptome Sequencing

Grant

Grant 1
TitleGrant-in-Aid for Scientific Research (C)
AgencyThe Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
Grant ID15K10732
Grant 2
TitleResearch grant to the RIKEN Preventive Medicine and Diagnosis Innovation Program
AgencyThe Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
Grant ID
Grant 3
TitleResearch grant to RIKEN Center for Life Science Technologies
AgencyThe Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
Grant ID
Grant 4
TitleResearch grant to RIKEN Omics Science Center
AgencyThe Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
Grant ID

Publication

PubMed ID29074988
Publication Statuspublished
DB TypePUBMED

Study Attribute

NBDC Numberhum0118
Registration date2017-11-30
Submitting organizationRIKEN Preventive Medicine and Diagnosis Innovation Program
Principal InvestigatorYoshihide Hayashizaki
Molecular Data TypeTranscriptome (Cap Analysis Of Gene Expression)
PlatformHiSeq2500
VendorIllumina
Comment
Molecular Data TypeTACC2 cDNA amplicon cloning and sequencing
Platformsanger sequencing
VendorThermo Fisher
Comment
Primary PhenotypeEndometrial carcinoma
Disease TypeNeoplasms
Dataset
Accession Title Dataset type Data objects Policy
JGAD00000000135 CAGE analysis for endometrial carcinoma, and TACC2 isoforms in endometrial carcinoma Transcriptome profiling by high-throughput sequencing 15 JGAP00000000001