Study: JGAS00000000135

Identifier

AccessionJGAS00000000135

Description

TitleTreg cell subset-specific gene expression patterns in human head and neck cancer
AbstractBackgrand: The occurrence of head and neck cancer has been increased all over the world. Although the prognosis has been improved by using several treatment modalities including immunotherapy, it is still unsatisfying. It is still unclear why the immunotherapy is effective only for partial amount of patients. To resolve this problem and to make a new treatment strategy based on human immune system, further investigation of antitumor immunity is required. Regulatory T (Treg) cells play critical roles in human immune responses including antitumor immunity. Therefore, the research to elucidate Treg function is strongly urged to clarify the mechanisms of antitumor immunity. Methods: We performed RNA-seuencing analysis of regulatory T cells infiltrating head and neck cancer. We devided into four populations, DP, CD25+, CTLA4+, DN and analyzed gene expressions. Results: The gene expression patterns of Treg-related genes were different between CD25+ cells and CD25- cells. Furthermore, DP cells had unique gene expression pattern compared to other populations. Conclusions: We found Treg cells infiltrating head and neck cancer had high expression levels of Treg-related genes and DP cells had unique gene expression pattern that may become a target of new treatment strategy. Regulatory T (Treg) cells play critical roles in human immune responses including antitumor immunity. Therefore, the research to elucidate Treg function is strongly urged to clarify the mechanisms of antitumor immunity.
Study Type
Study TypeTranscriptome Sequencing

Publication

PubMed ID30485427
Publication Statuspublished
DB TypePUBMED

Study Attribute

NBDC Numberhum0141
Registration date2018-05-16
Submitting organizationDepartment of Immunology, Nagoya City University Graduate School of Medical Sciences
Principal InvestigatorSayuri Yamazaki
Molecular Data TypeTranscriptome Sequencing
PlatformIon S5
VendorThermo Fisher Scientific
Comment
Primary PhenotypeNeoplasm of head and neck
Dataset
Accession Title Dataset type Data objects Policy
JGAD00000000204 Treg cells in head and neck cancer Transcriptome profiling by high-throughput sequencing 15 JGAP00000000001