Study: JGAS00000000137

Identifier

AccessionJGAS00000000137

Description

TitleWhole genome sequencing and mutation rate analysis of Vietnamese trios with paternal dioxin exposure
Abstract2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or dioxin, is commonly considered the most toxic man-made substance, and from 1962 to 1971, more than 19 million gallons of Agent Orange (AO) and other toxic chemicals contaminated with dioxin were sprayed in South of Vietnam. Dioxin exposure impacts human health and diseases, and birth defects and teratogenesis were frequently observed in children of persons who have been exposed to dioxin in Vietnam. However, the impact of dioxin on human mutation rate has not yet been analyzed. To identify and characterize the genetic alterations in the individuals exposed to dioxin, we perfomed whole genome sequencing of nine Vietnamese trios whose fathers were exposed to dioxin.
Study Type 1
Study TypeWhole Genome Sequencing
Study Type 2
Study TypeParent-Offspring Trios

Publication

PubMed ID29969170
Publication Statuspublished
DB TypePUBMED

Study Attribute

NBDC Numberhum0132
Registration date2018-05-07
Submitting organizationRIKEN Center for Integrative Medical Sciences
Principal InvestigatorHidewaki Nakagawa
Molecular Data TypeWhole Genome Sequencing
PlatformHiSeq 2000
VendorIllumina
Comment
Molecular Data TypeWhole Genome Sequencing
PlatformHiSeq 2500
VendorIllumina
Comment
Dataset
Accession Title Dataset type Data objects Policy
JGAD00000000206 Whole genome sequencing and mutation rate analysis of Vietnamese trios with paternal dioxin exposure Whole genome sequencing 38 JGAP00000000001