Study: JGAS00000000169




TitleWhole exome sequencing of uterine adenomyosis
AbstractUterine adenomyosis, defined by proliferation of the ectopic endometrial glands in myometrium, is a common benign uterine disorder that significantly impairs the quality of life of the women it affects. Adenomyosis lesions have chronic inflammatory reactions as well as cancer-like features such as invasive capacity into the normal myometrium. In contrast to endometriosis and leiomyoma, the genomic characterization of adenomyosis has yet to be reported. We conducted high-coverage whole exome sequencing analyses of freshly frozen adenomyosis samples, as well as co-occurring leiomyoma. Our WES analyses showed that adenomyosis is a clonal disorder with somatic mutations.
Study Type
Study TypeExome Sequencing

Study Attribute

NBDC Numberhum0168
Registration date2019-03-11
Submitting organizationNational Cancer Center Research Institute
Principal InvestigatorHiroyuki Mano
Molecular Data TypeWhole Exome Sequencing
PlatformHiSeq 2500
Primary Phenotypea common benign uterine disorder
Accession Title Dataset type Data objects Policy
JGAD00000000247 Exome bam files of uterine adenomyosis 229 JGAP00000000001