<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<STUDY_SET>
    <STUDY accession="DRP000139" center_name="UT-MGS" alias="DRP000139">
        <IDENTIFIERS>
            <PRIMARY_ID label="BioProject ID">PRJDA34559</PRIMARY_ID>
        </IDENTIFIERS>
        <DESCRIPTOR>
            <STUDY_TITLE>Comprehensive identification and characterization of the binding sites in H1299
            cells</STUDY_TITLE>
            <STUDY_TYPE new_study_type="" existing_study_type="Transcriptome Analysis"/>
            <STUDY_ABSTRACT>Comprehensive identification and characterization of the binding sites of
            H1299 cells. We used ChIP-Seq method, in which next gene sequencing technology and
            chromatin-immunoprecipitation assay were combined.</STUDY_ABSTRACT>
            <CENTER_PROJECT_NAME>Integrateve Transcriptome Analysis</CENTER_PROJECT_NAME>
            <RELATED_STUDIES>
                <RELATED_STUDY>
                    <RELATED_LINK>
                        <DB>bioproject</DB>
                        <ID>PRJDA34559</ID>
                        <LABEL>PRJDA34559</LABEL>
                    </RELATED_LINK>
                    <IS_PRIMARY>true</IS_PRIMARY>
                </RELATED_STUDY>
                <RELATED_STUDY>
                    <RELATED_LINK>
                        <DB>genomeprj</DB>
                        <ID>34559</ID>
                        <LABEL>34559</LABEL>
                    </RELATED_LINK>
                    <IS_PRIMARY>false</IS_PRIMARY>
                </RELATED_STUDY>
            </RELATED_STUDIES>
            <STUDY_DESCRIPTION>Although recent studies have revealed that the majority of human genes
            are subjected to regulation of alternative promoters (APs), the biological relevance of
            this phenomenon remains unclear. In order to understand biological significance of the
            presence of divergent transcription initiation events in the respective cell types, it
            is indispensable to obtain bird-view of the transcriptome figures at every step of the
            gene expression; namely, i) how the genomic structure change to transcriptionally active
            form, ii) where the transcription initiation complex is recruited, iii) to what extent
            the transcription is activated, iv) what transcripts formed and sorted to what
            subcellular fractions. We have recently started multi-faceted use of the Illumina GA to
            answer these questions. Integrative analysis produced for respective aspects of the gene
            expression regulations revealed the comprehensive figures of the complex human gene
            transcriptome for the first time.</STUDY_DESCRIPTION>
        </DESCRIPTOR>
        <STUDY_LINKS>
            <STUDY_LINK>
                <URL_LINK>
                    <LABEL>DBTSS</LABEL>
                    <URL>http://dbtss.hgc.jp</URL>
                </URL_LINK>
            </STUDY_LINK>
        </STUDY_LINKS>
    </STUDY>
</STUDY_SET>
