<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<STUDY_SET>
    <STUDY accession="DRP002419" center_name="KYUSH-MS" alias="DRP002419">
        <IDENTIFIERS>
            <PRIMARY_ID label="BioProject ID">PRJDB3301</PRIMARY_ID>
        </IDENTIFIERS>
        <DESCRIPTOR>
            <STUDY_TITLE>Small non-coding RNA sequencing of MeCP2-deficient cells</STUDY_TITLE>
            <STUDY_TYPE existing_study_type="Other"/>
            <STUDY_ABSTRACT>Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked geneMECP2. However, molecular mechanisms of how MeCP2 deficiency leads to RTT pathogenesis are largely unknown. In this study, we performed the deep RNA sequencing using small non-coding RNA fraction from WT or MeCP2-KO neurons and WT or MeCP2 NSCs to identify microRNA that are regulated by MeCP2.</STUDY_ABSTRACT>
            <CENTER_PROJECT_NAME>Small non-coding RNA sequencing of MeCP2-deficient cells</CENTER_PROJECT_NAME>
            <RELATED_STUDIES>
                <RELATED_STUDY>
                    <RELATED_LINK>
                        <DB>bioproject</DB>
                        <ID>PRJDB3301</ID>
                        <LABEL>PRJDB3301</LABEL>
                    </RELATED_LINK>
                    <IS_PRIMARY>true</IS_PRIMARY>
                </RELATED_STUDY>
            </RELATED_STUDIES>
            <STUDY_DESCRIPTION>Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked geneMECP2. However, molecular mechanisms of how MeCP2 deficiency leads to RTT pathogenesis are largely unknown. In this study, we performed the deep RNA sequencing using small non-coding RNA fraction from WT or MeCP2-KO neurons and WT or MeCP2 NSCs to identify microRNA that are regulated by MeCP2.</STUDY_DESCRIPTION>
        </DESCRIPTOR>
    </STUDY>
</STUDY_SET>
