PRJDB11666 16S rRNA gene and metagenomic sequencing analysis of deep granitic groundwater 16S rRNA gene miseq sequencing and metagenomic sequencing were performed for deep granitic groundwater to profile microbial communities and reconstruct metabolism in the subsurface. High-quality groundwater was collected from underground boreholes drilled at Mizunami Underground Research Laboratory in central Japan. 16S rRNA gene and metagenomic sequencing analysis of deep granitic groundwater bioproject PRJDB11666 PRJDB11666 true 16S rRNA gene miseq sequencing and metagenomic sequencing were performed for deep granitic groundwater to profile microbial communities and reconstruct metabolism in the subsurface. High-quality groundwater was collected from underground boreholes drilled at Mizunami Underground Research Laboratory in central Japan.