<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<STUDY_SET>
    <STUDY alias="DRP010531" center_name="NCCRI" accession="DRP010531">
        <IDENTIFIERS>
            <PRIMARY_ID label="BioProject ID">PRJDB16573</PRIMARY_ID>
        </IDENTIFIERS>
        <DESCRIPTOR>
            <STUDY_TITLE>Single cell RNA-seq analysis of mouse colonic organoids</STUDY_TITLE>
            <STUDY_TYPE existing_study_type="Other"/>
            <STUDY_ABSTRACT>In the analysis of inflamation-associated colorectal cancer, mouse colonic organoids were treated with or without TNF alpha. Organoids were dissociated into single cells, and scRNA-seq was performed using the Chromium Single cell 3' library kit v3. Simultaneous induction of senescence signaling and stemness was observed by TNF alpha treatment.</STUDY_ABSTRACT>
            <CENTER_PROJECT_NAME>Single cell RNA-seq analysis of mouse colonic organoids</CENTER_PROJECT_NAME>
            <RELATED_STUDIES>
                <RELATED_STUDY>
                    <RELATED_LINK>
                        <DB>bioproject</DB>
                        <ID>PRJDB16573</ID>
                        <LABEL>PRJDB16573</LABEL>
                    </RELATED_LINK>
                    <IS_PRIMARY>true</IS_PRIMARY>
                </RELATED_STUDY>
            </RELATED_STUDIES>
            <STUDY_DESCRIPTION>In the analysis of inflamation-associated colorectal cancer, mouse colonic organoids were treated with or without TNF alpha. Organoids were dissociated into single cells, and scRNA-seq was performed using the Chromium Single cell 3' library kit v3. Simultaneous induction of senescence signaling and stemness was observed by TNF alpha treatment.</STUDY_DESCRIPTION>
        </DESCRIPTOR>
    </STUDY>
</STUDY_SET>
