ERP104936 PRJEB23199 ena-STUDY-Spedding Research Solutions, SAS-26-10-2017-11:26:30:513-645 RNAseq data from spinal cord samples of SOD1 G86R mice Lipid metabolism is drastically dysregulated in amyotrophic lateral sclerosis and impacts prognosis of patients. Animal models recapitulate alterations in the energy metabolism, including hypermetabolism and severe loss of adipose tissue. To gain insight into the molecular mechanisms underlying disease progression in amyotrophic lateral sclerosis, we have performed RNA sequencing of spinal cord of symptomatic SOD1G86R mice. Spinal transcriptome of SOD1G86R mice was characterized by differential expression of genes related to immune system, extracellular exosome, lysosome and complex lipids. Joint analysis Spc SOD1 mice Lipid metabolism is drastically dysregulated in amyotrophic lateral sclerosis and impacts prognosis of patients. Animal models recapitulate alterations in the energy metabolism, including hypermetabolism and severe loss of adipose tissue. To gain insight into the molecular mechanisms underlying disease progression in amyotrophic lateral sclerosis, we have performed RNA sequencing of spinal cord of symptomatic SOD1G86R mice. Spinal transcriptome of SOD1G86R mice was characterized by differential expression of genes related to immune system, extracellular exosome, lysosome and complex lipids. ENA-FIRST-PUBLIC 2017-12-25 ENA-LAST-UPDATE 2017-10-26