ERP112223 PRJEB29873 E-MTAB-7411 3prime RNA-seq of murine SCLC cell line modified with CRISPR-activation of Myc, Mycl or Mycn In cells derived from a genetically engineered Rb1 and Trp53 loss mouse model of SCLC (RP) expression of one of the three MYC family members induced from the endogenous locus using CRISPR activation. Cells were first stably transfected with the lenti-MS2-p65-HSF1 activator plasmid. Respective sgRNAs targeting either Myc, Mycl or MYCN were then cloned into the lentiSAMv2 system and transfected separately into the MS2-p65-HSF1 cells using lentiviral delivery. In cells derived from a genetically engineered Rb1 and Trp53 loss mouse model of SCLC (RP) expression of one of the three MYC family members induced from the endogenous locus using CRISPR activation. Cells were first stably transfected with the lenti-MS2-p65-HSF1 activator plasmid. Respective sgRNAs targeting either Myc, Mycl or MYCN were then cloned into the lentiSAMv2 system and transfected separately into the MS2-p65-HSF1 cells using lentiviral delivery. E-MTAB-7411 in ArrayExpress http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-7411 ENA-FIRST-PUBLIC 2019-07-09 ENA-LAST-UPDATE 2018-11-21