ERP116965 PRJEB34109 ena-STUDY-UNIVERSITY OF SYDNEY-23-08-2019-05:18:37:796-143 High-fibre diet prolongs kidney allograft survival in a murine model of renal transplantation Wild type C57BL/6 mice recipients of BALB/c allograft kidneys display prolonged survival when maintained on a high-fiber diet, compared to allograft recipients fed normal mouse chow. High-fiber fed mice display significant differences in key gut microbiota species, such as Bifidobacterium, which likely mediate the survival benefit seen. Gut Microbial Metabolites Induce Donor Specific Tolerance of Kidney Allografts through SCFA Induction of T Regulatory Cells Wild type C57BL/6 mice recipients of BALB/c allograft kidneys display prolonged survival when maintained on a high-fiber diet, compared to allograft recipients fed normal mouse chow. High-fiber fed mice display significant differences in key gut microbiota species, such as Bifidobacterium, which likely mediate the survival benefit seen. ENA-FIRST-PUBLIC 2019-08-23 ENA-LAST-UPDATE 2019-08-23