ERP117352 PRJEB34446 ena-STUDY-INSTITUTE OF PATHOLOGY-17-09-2019-09:59:08:083-16 Genetic evolution of in situ follicular neoplasia to aggressive B-cell lymphoma of germinal center subtype We provide first evidence that t(14;18)+ aggressive B-NHL may arise directly from ISFN and that during this progression, branched evolution is common. Evolution of ISFN to DLBCL We provide first evidence that t(14;18)+ aggressive B-NHL may arise directly from ISFN and that during this progression, branched evolution is common. ENA-FIRST-PUBLIC 2019-09-20 ENA-LAST-UPDATE 2020-01-02