ERP125525 PRJEB41707 ena-STUDY-International School for Advanced Studies-03-12-2020-08:47:47:093-175 RNA-seq of CTR and dod mutant Drosophila heads Chromatin organization is crucial in tissue homeostasis. Heterochromatin decondensation and unscheduled mobilisation of transposable elements, associated with DNA damage, are emerging key contributors of aging and aging-related pathologies, including Alzheimer's disease (AD) and cancer. However, mechanisms preserving heterochromatin, and how in pathological conditions heterochromatin becomes decondensed, are still unclear. Importantly dod (PIN1) loss is associated with premature ageing and AD, maintains heterochromatin. Here we provide a Drosophila RNA-seq of controls and dod (PIN1) mutant Drosophila heads Chromatin organization is crucial in tissue homeostasis. Heterochromatin decondensation and unscheduled mobilisation of transposable elements, associated with DNA damage, are emerging key contributors of aging and aging-related pathologies, including Alzheimer's disease (AD) and cancer. However, mechanisms preserving heterochromatin, and how in pathological conditions heterochromatin becomes decondensed, are still unclear. Importantly dod (PIN1) loss is associated with premature ageing and AD, maintains heterochromatin. Here we provide a Drosophila RNA-seq of controls and dod (PIN1) mutant Drosophila heads ENA-FIRST-PUBLIC 2021-09-13 ENA-LAST-UPDATE 2021-09-13