ERP128071 PRJEB44066 E-MTAB-10295 SHP-1 dependent dephosphorylation of Histone H2B acts as a molecular switch to facilitate transcription 1.Comparison of chromatin occupancy of H2BUb and RNA Polymerase II in SHP-1 WT and KO MCF7 cells. Paired end sequencing (2X100 bp) was performed on the Illumina HiSeq X ten. 2.Identification of the SHP-1 binding site in MCF7 cells using ChIP Seq. Paired end sequencing (2X100 bp) was performed on the Illumina Nextseq 2000 platform. 1.Comparison of chromatin occupancy of H2BUb and RNA Polymerase II in SHP-1 WT and KO MCF7 cells. Paired end sequencing (2X100 bp) was performed on the Illumina HiSeq X ten. 2.Identification of the SHP-1 binding site in MCF7 cells using ChIP Seq. Paired end sequencing (2X100 bp) was performed on the Illumina Nextseq 2000 platform. E-MTAB-10295 in ArrayExpress http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-10295 ENA-FIRST-PUBLIC 2022-06-01 ENA-LAST-UPDATE 2022-06-01