ERP014559 PRJEB13021 ena-STUDY-ONTARIO INSTITUTE FOR CANCER RESEARCH-14-03-2016-15:26:45:302-131 Detecting methylation using the MinION We assess the potential for detecting 5-methylcytosine using the Oxford Nanopore Technologies' MinION sequencer. We trained a hidden Markov model using enzymatically methylated E. coli DNA. We test the accuracy of this model using natural human DNA from a cell line. Nanopore methylation We assess the potential for detecting 5-methylcytosine using the Oxford Nanopore Technologies' MinION sequencer. We trained a hidden Markov model using enzymatically methylated E. coli DNA. We test the accuracy of this model using natural human DNA from a cell line.