ERP014590 PRJEB13052 E-MTAB-4528 E-MTAB-4528 Cold induced transcriptome change in skeletal muscle Exposure to cold temperatures is known to mimic the effects of exercise, protecting against obesity and improving metabolic health. Cold is known to act through the sympathetic nervous systems and ß-adrenergic signaling, but here we report that cold temperature can directly activate a variety of gene programs in muscle independent of ß-adrenergic signaling. Exposure to cold temperatures is known to mimic the effects of exercise, protecting against obesity and improving metabolic health. Cold is known to act through the sympathetic nervous systems and ß-adrenergic signaling, but here we report that cold temperature can directly activate a variety of gene programs in muscle independent of ß-adrenergic signaling. E-MTAB-4528 in ArrayExpress http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-4528 ENA-FIRST-PUBLIC 2017-10-27 ENA-LAST-UPDATE 2016-03-15 ArrayExpress E-MTAB-4528