ERP016429 PRJEB14761 E-MTAB-4912 RNA-Seq in liver of Tc1 mice carrying human chromosome 21 passaged through either the female or male germline This study aims to investigate whether the passage of human chromosome 21 through the mouse male germline results in changes in the transcriptional deployment of the exogenous chromosome in the offspring generation. We used the Tc1 mouse model that stably carries almost an entire copy of human chromosome 21 and profiled transcription in the livers of male- and female-germline derived Tc1 mice using strand-specific total RNA-Seq This study aims to investigate whether the passage of human chromosome 21 through the mouse male germline results in changes in the transcriptional deployment of the exogenous chromosome in the offspring generation. We used the Tc1 mouse model that stably carries almost an entire copy of human chromosome 21 and profiled transcription in the livers of male- and female-germline derived Tc1 mice using strand-specific total RNA-Seq E-MTAB-4912 in ArrayExpress http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-4912 ArrayExpress E-MTAB-4912