SRX8774924 GSM4678200 SRP272624 SRS7045385 GSM4678200 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated with the use of QIAzol Lysis (Qiagen) followed by isopropanol precipitation. Then, concentration and integrity RNAestimated with the use of Fragment Analyzer (Agilent) and Qubit 4 Fluorometer (Thermo Fisher). Poly-A tail mRNA was enriched using magnetic beads. First stand of cDNA was synthesized using SuperScript III Reverse Transcriptase (Thermo Fisher), and second strand was synthesized using the second strand master mix (TruSeq RNA Library Prep Kit V2 (Illumina)). The synthesized DNA was cleaned up with the use of AgencourtAMPure XP Beads (Beckman Coulter). After, end repair/dA-tailing, adaptors were ligated, and the library was further enriched with the use of TruSeq RNA Library Prep Kit V2 (Illumina). After determining quality and concentration, the cDNA libraries were pooled and loaded (20 pM) into the NextSeq 500 (Illumina) Sequencer with the use of NextSeq 500/550 High Output Kit v2.5(75 cycles). NextSeq 500 gds 304678200 GSM4678200 GEO Accession GSM4678200 SRX8774925 GSM4678201 SRP272624 SRS7045386 GSM4678201 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated with the use of QIAzol Lysis (Qiagen) followed by isopropanol precipitation. Then, concentration and integrity RNAestimated with the use of Fragment Analyzer (Agilent) and Qubit 4 Fluorometer (Thermo Fisher). Poly-A tail mRNA was enriched using magnetic beads. First stand of cDNA was synthesized using SuperScript III Reverse Transcriptase (Thermo Fisher), and second strand was synthesized using the second strand master mix (TruSeq RNA Library Prep Kit V2 (Illumina)). The synthesized DNA was cleaned up with the use of AgencourtAMPure XP Beads (Beckman Coulter). After, end repair/dA-tailing, adaptors were ligated, and the library was further enriched with the use of TruSeq RNA Library Prep Kit V2 (Illumina). After determining quality and concentration, the cDNA libraries were pooled and loaded (20 pM) into the NextSeq 500 (Illumina) Sequencer with the use of NextSeq 500/550 High Output Kit v2.5(75 cycles). NextSeq 500 gds 304678201 GSM4678201 GEO Accession GSM4678201 SRX8774926 GSM4678202 SRP272624 SRS7045387 GSM4678202 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated with the use of QIAzol Lysis (Qiagen) followed by isopropanol precipitation. Then, concentration and integrity RNAestimated with the use of Fragment Analyzer (Agilent) and Qubit 4 Fluorometer (Thermo Fisher). Poly-A tail mRNA was enriched using magnetic beads. First stand of cDNA was synthesized using SuperScript III Reverse Transcriptase (Thermo Fisher), and second strand was synthesized using the second strand master mix (TruSeq RNA Library Prep Kit V2 (Illumina)). The synthesized DNA was cleaned up with the use of AgencourtAMPure XP Beads (Beckman Coulter). After, end repair/dA-tailing, adaptors were ligated, and the library was further enriched with the use of TruSeq RNA Library Prep Kit V2 (Illumina). After determining quality and concentration, the cDNA libraries were pooled and loaded (20 pM) into the NextSeq 500 (Illumina) Sequencer with the use of NextSeq 500/550 High Output Kit v2.5(75 cycles). NextSeq 500 gds 304678202 GSM4678202 GEO Accession GSM4678202 SRX8774927 GSM4678203 SRP272624 SRS7045389 GSM4678203 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated with the use of QIAzol Lysis (Qiagen) followed by isopropanol precipitation. Then, concentration and integrity RNAestimated with the use of Fragment Analyzer (Agilent) and Qubit 4 Fluorometer (Thermo Fisher). Poly-A tail mRNA was enriched using magnetic beads. First stand of cDNA was synthesized using SuperScript III Reverse Transcriptase (Thermo Fisher), and second strand was synthesized using the second strand master mix (TruSeq RNA Library Prep Kit V2 (Illumina)). The synthesized DNA was cleaned up with the use of AgencourtAMPure XP Beads (Beckman Coulter). After, end repair/dA-tailing, adaptors were ligated, and the library was further enriched with the use of TruSeq RNA Library Prep Kit V2 (Illumina). After determining quality and concentration, the cDNA libraries were pooled and loaded (20 pM) into the NextSeq 500 (Illumina) Sequencer with the use of NextSeq 500/550 High Output Kit v2.5(75 cycles). NextSeq 500 gds 304678203 GSM4678203 GEO Accession GSM4678203 SRX8774928 GSM4678204 SRP272624 SRS7045388 GSM4678204 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated with the use of QIAzol Lysis (Qiagen) followed by isopropanol precipitation. Then, concentration and integrity RNAestimated with the use of Fragment Analyzer (Agilent) and Qubit 4 Fluorometer (Thermo Fisher). Poly-A tail mRNA was enriched using magnetic beads. First stand of cDNA was synthesized using SuperScript III Reverse Transcriptase (Thermo Fisher), and second strand was synthesized using the second strand master mix (TruSeq RNA Library Prep Kit V2 (Illumina)). The synthesized DNA was cleaned up with the use of AgencourtAMPure XP Beads (Beckman Coulter). After, end repair/dA-tailing, adaptors were ligated, and the library was further enriched with the use of TruSeq RNA Library Prep Kit V2 (Illumina). After determining quality and concentration, the cDNA libraries were pooled and loaded (20 pM) into the NextSeq 500 (Illumina) Sequencer with the use of NextSeq 500/550 High Output Kit v2.5(75 cycles). NextSeq 500 gds 304678204 GSM4678204 GEO Accession GSM4678204 SRX8774929 GSM4678205 SRP272624 SRS7045390 GSM4678205 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated with the use of QIAzol Lysis (Qiagen) followed by isopropanol precipitation. Then, concentration and integrity RNAestimated with the use of Fragment Analyzer (Agilent) and Qubit 4 Fluorometer (Thermo Fisher). Poly-A tail mRNA was enriched using magnetic beads. First stand of cDNA was synthesized using SuperScript III Reverse Transcriptase (Thermo Fisher), and second strand was synthesized using the second strand master mix (TruSeq RNA Library Prep Kit V2 (Illumina)). The synthesized DNA was cleaned up with the use of AgencourtAMPure XP Beads (Beckman Coulter). After, end repair/dA-tailing, adaptors were ligated, and the library was further enriched with the use of TruSeq RNA Library Prep Kit V2 (Illumina). After determining quality and concentration, the cDNA libraries were pooled and loaded (20 pM) into the NextSeq 500 (Illumina) Sequencer with the use of NextSeq 500/550 High Output Kit v2.5(75 cycles). NextSeq 500 gds 304678205 GSM4678205 GEO Accession GSM4678205 SRX8774930 GSM4678206 SRP272624 SRS7045391 GSM4678206 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated with the use of QIAzol Lysis (Qiagen) followed by isopropanol precipitation. Then, concentration and integrity RNAestimated with the use of Fragment Analyzer (Agilent) and Qubit 4 Fluorometer (Thermo Fisher). Poly-A tail mRNA was enriched using magnetic beads. First stand of cDNA was synthesized using SuperScript III Reverse Transcriptase (Thermo Fisher), and second strand was synthesized using the second strand master mix (TruSeq RNA Library Prep Kit V2 (Illumina)). The synthesized DNA was cleaned up with the use of AgencourtAMPure XP Beads (Beckman Coulter). After, end repair/dA-tailing, adaptors were ligated, and the library was further enriched with the use of TruSeq RNA Library Prep Kit V2 (Illumina). After determining quality and concentration, the cDNA libraries were pooled and loaded (20 pM) into the NextSeq 500 (Illumina) Sequencer with the use of NextSeq 500/550 High Output Kit v2.5(75 cycles). NextSeq 500 gds 304678206 GSM4678206 GEO Accession GSM4678206 SRX8774931 GSM4678207 SRP272624 SRS7045392 GSM4678207 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated with the use of QIAzol Lysis (Qiagen) followed by isopropanol precipitation. Then, concentration and integrity RNAestimated with the use of Fragment Analyzer (Agilent) and Qubit 4 Fluorometer (Thermo Fisher). Poly-A tail mRNA was enriched using magnetic beads. First stand of cDNA was synthesized using SuperScript III Reverse Transcriptase (Thermo Fisher), and second strand was synthesized using the second strand master mix (TruSeq RNA Library Prep Kit V2 (Illumina)). The synthesized DNA was cleaned up with the use of AgencourtAMPure XP Beads (Beckman Coulter). After, end repair/dA-tailing, adaptors were ligated, and the library was further enriched with the use of TruSeq RNA Library Prep Kit V2 (Illumina). After determining quality and concentration, the cDNA libraries were pooled and loaded (20 pM) into the NextSeq 500 (Illumina) Sequencer with the use of NextSeq 500/550 High Output Kit v2.5(75 cycles). NextSeq 500 gds 304678207 GSM4678207 GEO Accession GSM4678207