SRX8804924 GSM4684859 SRP273234 SRS7071409 GSM4684859 RNA-Seq TRANSCRIPTOMIC cDNA For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684859 GSM4684859 GEO Accession GSM4684859 SRX8804925 GSM4684860 SRP273234 SRS7071410 GSM4684860 RNA-Seq TRANSCRIPTOMIC cDNA For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684860 GSM4684860 GEO Accession GSM4684860 SRX8804926 GSM4684861 SRP273234 SRS7071411 GSM4684861 RNA-Seq TRANSCRIPTOMIC cDNA For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684861 GSM4684861 GEO Accession GSM4684861 SRX8804927 GSM4684862 SRP273234 SRS7071412 GSM4684862 RNA-Seq TRANSCRIPTOMIC cDNA For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684862 GSM4684862 GEO Accession GSM4684862 SRX8804928 GSM4684863 SRP273234 SRS7071413 GSM4684863 RNA-Seq TRANSCRIPTOMIC cDNA For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684863 GSM4684863 GEO Accession GSM4684863 SRX8804929 GSM4684864 SRP273234 SRS7071414 GSM4684864 RNA-Seq TRANSCRIPTOMIC cDNA For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684864 GSM4684864 GEO Accession GSM4684864 SRX8804930 GSM4684865 SRP273234 SRS7071415 GSM4684865 RNA-Seq TRANSCRIPTOMIC cDNA For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684865 GSM4684865 GEO Accession GSM4684865 SRX8804931 GSM4684866 SRP273234 SRS7071416 GSM4684866 RNA-Seq TRANSCRIPTOMIC cDNA For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684866 GSM4684866 GEO Accession GSM4684866 SRX8804932 GSM4684867 SRP273234 SRS7071417 GSM4684867 RNA-Seq TRANSCRIPTOMIC cDNA For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684867 GSM4684867 GEO Accession GSM4684867 SRX8804933 GSM4684868 SRP273234 SRS7071418 GSM4684868 RNA-Seq TRANSCRIPTOMIC cDNA For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684868 GSM4684868 GEO Accession GSM4684868 SRX8804934 GSM4684869 SRP273234 SRS7071419 GSM4684869 RNA-Seq TRANSCRIPTOMIC cDNA For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684869 GSM4684869 GEO Accession GSM4684869 SRX8804935 GSM4684870 SRP273234 SRS7071420 GSM4684870 RNA-Seq TRANSCRIPTOMIC cDNA For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684870 GSM4684870 GEO Accession GSM4684870 SRX8804936 GSM4684871 SRP273234 SRS7071421 GSM4684871 ATAC-seq GENOMIC other For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684871 GSM4684871 GEO Accession GSM4684871 SRX8804937 GSM4684872 SRP273234 SRS7071422 GSM4684872 ATAC-seq GENOMIC other For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684872 GSM4684872 GEO Accession GSM4684872 SRX8804938 GSM4684873 SRP273234 SRS7071423 GSM4684873 ATAC-seq GENOMIC other For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684873 GSM4684873 GEO Accession GSM4684873 SRX8804939 GSM4684874 SRP273234 SRS7071424 GSM4684874 ATAC-seq GENOMIC other For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684874 GSM4684874 GEO Accession GSM4684874 SRX8804940 GSM4684875 SRP273234 SRS7071425 GSM4684875 ATAC-seq GENOMIC other For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684875 GSM4684875 GEO Accession GSM4684875 SRX8804941 GSM4684876 SRP273234 SRS7071426 GSM4684876 ATAC-seq GENOMIC other For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684876 GSM4684876 GEO Accession GSM4684876 SRX8804942 GSM4684877 SRP273234 SRS7071427 GSM4684877 RIP-Seq TRANSCRIPTOMIC other For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684877 GSM4684877 GEO Accession GSM4684877 SRX8804943 GSM4684878 SRP273234 SRS7071428 GSM4684878 RIP-Seq TRANSCRIPTOMIC other For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684878 GSM4684878 GEO Accession GSM4684878 SRX8804944 GSM4684879 SRP273234 SRS7071429 GSM4684879 RIP-Seq TRANSCRIPTOMIC other For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684879 GSM4684879 GEO Accession GSM4684879 SRX8804945 GSM4684880 SRP273234 SRS7071430 GSM4684880 RIP-Seq TRANSCRIPTOMIC other For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684880 GSM4684880 GEO Accession GSM4684880 SRX8804946 GSM4684881 SRP273234 SRS7071431 GSM4684881 RIP-Seq TRANSCRIPTOMIC other For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684881 GSM4684881 GEO Accession GSM4684881 SRX8804947 GSM4684882 SRP273234 SRS7071432 GSM4684882 RIP-Seq TRANSCRIPTOMIC other For RNA-seq, total RNAs were extracted using Trizol reagent (invitrogen). For m6A-seq, total RNAs in tumor cells were extracted using Trizol and polyadenylated RNAs were purified using the Dynabeads mRNA Purification Kit (Invitrogen). RNAs were fragmented into ~100-nucleotide-long fragments by using 10X Fragmentation Reagent(Invitrogen) at 94℃ for 45s and stopped by the 10X Stop Solution(Invitrogen). EpiMark N6-methyladenosine enrichment kit (NEB E1610S) was used for m6A immunoprecipitation (m6A-IP) to enrich the m6A marked RNAs followed by RNA extraction by Trizol. For ATAC-seq, 5 × 104 B16-OVA-shNC or shFto cells were first lysed with ATAC RSB buffer containing 0.1% NP40, 0.1% Tween-20, and 0.01% Digitonin on ice for 3 minutes. Then cell lyates were centrifuged to collecte the cell nuclei. After a wash step, the cell nuclei were ready for library construction. For RNA-seq and m6A-seq, the library construction was performed with SMARTer Stranded Total RNA-Seq Kit (Takara). For ATAC-seq, the libraries were constructed by using TruePrep DNA Library Prep Kit V2 for illumine (Vazyme). HiSeq X Ten gds 304684882 GSM4684882 GEO Accession GSM4684882