<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE167531" accession="SRP308200">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP308200</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA704903</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE167531</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>Genome-wide maps of chromatin state in cultured male germline stem cells with retinoic acid treatment [scATAC-seq]</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Whole Genome Sequencing"/>
      <STUDY_ABSTRACT>We report the application of single-cell ATAC-seq to reconstruct the epigenetic program and differentiation trajectory associated with the retinoic acid (RA)-induced differentiation in cultured male germline stem cells (GSCs). We also identified key transcription factors and regulatory elements regulated by RA. Overall design: Chromatin accessibility profiles of retinoic acid-treated GSCs.</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE167531</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
    <STUDY_LINKS>
      <STUDY_LINK>
        <XREF_LINK>
          <DB>pubmed</DB>
          <ID>36509798</ID>
        </XREF_LINK>
      </STUDY_LINK>
    </STUDY_LINKS>
  </STUDY>
</STUDY_SET>
