SRX10206034 GSM5124259 GSM5124259: WT+GCV_747; Mus musculus; RNA-Seq SRP308831 SRS8351959 GSM5124259 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124259 GEO Accession GSM5124259 SRX10206035 GSM5124260 GSM5124260: WT+GCV_763; Mus musculus; RNA-Seq SRP308831 SRS8351960 GSM5124260 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124260 GEO Accession GSM5124260 SRX10206036 GSM5124261 GSM5124261: WT+GCV_880; Mus musculus; RNA-Seq SRP308831 SRS8351962 GSM5124261 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124261 GEO Accession GSM5124261 SRX10206037 GSM5124262 GSM5124262: WT+GCV_1209; Mus musculus; RNA-Seq SRP308831 SRS8351963 GSM5124262 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124262 GEO Accession GSM5124262 SRX10206038 GSM5124263 GSM5124263: WT+GCV_995; Mus musculus; RNA-Seq SRP308831 SRS8351961 GSM5124263 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124263 GEO Accession GSM5124263 SRX10206039 GSM5124264 GSM5124264: p16-3MR+GCV_645; Mus musculus; RNA-Seq SRP308831 SRS8351965 GSM5124264 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124264 GEO Accession GSM5124264 SRX10206040 GSM5124265 GSM5124265: p16-3MR+GCV_726; Mus musculus; RNA-Seq SRP308831 SRS8351964 GSM5124265 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124265 GEO Accession GSM5124265 SRX10206041 GSM5124266 GSM5124266: p16-3MR+GCV_751; Mus musculus; RNA-Seq SRP308831 SRS8351967 GSM5124266 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124266 GEO Accession GSM5124266 SRX10206042 GSM5124267 GSM5124267: p16-3MR+GCV_761; Mus musculus; RNA-Seq SRP308831 SRS8351968 GSM5124267 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124267 GEO Accession GSM5124267 SRX10206043 GSM5124268 GSM5124268: p16-3MR+GCV_776; Mus musculus; RNA-Seq SRP308831 SRS8351969 GSM5124268 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124268 GEO Accession GSM5124268 SRX10206044 GSM5124269 GSM5124269: p16-3MR+GCV_536; Mus musculus; RNA-Seq SRP308831 SRS8351966 GSM5124269 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124269 GEO Accession GSM5124269 SRX10206045 GSM5124270 GSM5124270: p16-3MR+GCV_641; Mus musculus; RNA-Seq SRP308831 SRS8351970 GSM5124270 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124270 GEO Accession GSM5124270 SRX10206046 GSM5124271 GSM5124271: p16-3MR+GCV_762; Mus musculus; RNA-Seq SRP308831 SRS8351971 GSM5124271 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124271 GEO Accession GSM5124271 SRX10206047 GSM5124272 GSM5124272: p16-3MR+GCV_773; Mus musculus; RNA-Seq SRP308831 SRS8351972 GSM5124272 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124272 GEO Accession GSM5124272 SRX10206048 GSM5124273 GSM5124273: p16-3MR+vhc_861; Mus musculus; RNA-Seq SRP308831 SRS8351973 GSM5124273 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124273 GEO Accession GSM5124273 SRX10206049 GSM5124274 GSM5124274: p16-3MR+vhc_869; Mus musculus; RNA-Seq SRP308831 SRS8351976 GSM5124274 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124274 GEO Accession GSM5124274 SRX10206050 GSM5124275 GSM5124275: p16-3MR+vhc_765; Mus musculus; RNA-Seq SRP308831 SRS8351974 GSM5124275 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124275 GEO Accession GSM5124275 SRX10206051 GSM5124276 GSM5124276: p16-3MR+vhc_997; Mus musculus; RNA-Seq SRP308831 SRS8351975 GSM5124276 RNA-Seq TRANSCRIPTOMIC cDNA GBM mouse model: Total RNA were extracted from GBM samples following TRI-reagent protocol (Molecular Center Research, TR 118). GBM-derived organoids: Total RNA from 3 pooled GBM-derived organoids were extracted following the Macherey-Nagel Mini kit Nucleospin protocol (Macherey-Nagel, 740955.50). Illumina NovaSeq 6000 gds 305124276 GEO Accession GSM5124276