SRP311079 PRJNA715200 GSE169091 RAC1 is an essential cofactor for estrogen receptor alpha [RNA-seq 2] We identified a small GTPase protein RAC1 as an intrinsic cofactor in the estrogen receptor alpha (ER) complex that is required for the function of ER. Overall design: MCF-7 cells were estrogen-deprived for 3 days before the cells were treated for 1 h during which the newly synthesized RNAs were labeled with BrU. The newly synthesized RNAs were purified and were subjected to RNA-seq. GSE169091 pubmed 34373577 parent_bioproject PRJNA715202