SRP311390 PRJNA715777 GSE169252 CD22 blockage restores age-related impairments of microglia surveillance capacity We report that antibody-mediated CD22 blockage leads to an altered transcriptomic signature profile which, by further evaluating the affected genes, resembles a homeostatic phenotype. Overall design: Assessment of RNA expression levels following antibody-mediated blockage of CD22 in human iPSC-derived macrophages. GSE169252 pubmed 33613545 pubmed 34140954