SRP325436 PRJNA741048 SUPERNOVA - SUrveillance Platform for Enteric and Respiratory iNfectious Organisms in the VA The ongoing SUrveillance Platform for Enteric and Respiratory iNfectious Organisms in the VA, or SUPERNOVA, study is a collaboration between Emory University, the Centers for Disease Control and Prevention (CDC), and Veterans Affairs Medical Centers (VAMC) in Atlanta, GA, Houston, TX, Bronx, NY, Los Angeles, CA, and Palo Alto, CA. Here, we analyzed the microbiomes of a subgroup of 100 SUPERNOVA participants, both diarrhea cases and non-diarrhea controls. Our objectives were to assess for differences in microbiome diversity between participants by norovirus infection status as well as by secretor status. Additional analyses explored diversity differences by recent diarrhea and in microbiome composition (i.e. the overall microbial population of an individual) between norovirus and secretor status groups. Analysis repository https://github.com/Read-Lab-Confederation/supernova-16s