SRX11233323 GSM5402103 SRP325710 SRS9279442 GSM5402103 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402103 GSM5402103 GEO Accession GSM5402103 SRX11233324 GSM5402104 SRP325710 SRS9279444 GSM5402104 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402104 GSM5402104 GEO Accession GSM5402104 SRX11233325 GSM5402105 SRP325710 SRS9279443 GSM5402105 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402105 GSM5402105 GEO Accession GSM5402105 SRX11233326 GSM5402106 SRP325710 SRS9279445 GSM5402106 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402106 GSM5402106 GEO Accession GSM5402106 SRX11233327 GSM5402107 SRP325710 SRS9279446 GSM5402107 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402107 GSM5402107 GEO Accession GSM5402107 SRX11233328 GSM5402108 SRP325710 SRS9279447 GSM5402108 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402108 GSM5402108 GEO Accession GSM5402108 SRX11233329 GSM5402109 SRP325710 SRS9279448 GSM5402109 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402109 GSM5402109 GEO Accession GSM5402109 SRX11233330 GSM5402110 SRP325710 SRS9279449 GSM5402110 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402110 GSM5402110 GEO Accession GSM5402110 SRX11233331 GSM5402111 SRP325710 SRS9279450 GSM5402111 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402111 GSM5402111 GEO Accession GSM5402111 SRX11233332 GSM5402112 SRP325710 SRS9279452 GSM5402112 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402112 GSM5402112 GEO Accession GSM5402112 SRX11233333 GSM5402113 SRP325710 SRS9279451 GSM5402113 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402113 GSM5402113 GEO Accession GSM5402113 SRX11233334 GSM5402114 SRP325710 SRS9279453 GSM5402114 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402114 GSM5402114 GEO Accession GSM5402114 SRX11233335 GSM5402115 SRP325710 SRS9279454 GSM5402115 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402115 GSM5402115 GEO Accession GSM5402115 SRX11233336 GSM5402116 SRP325710 SRS9279456 GSM5402116 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402116 GSM5402116 GEO Accession GSM5402116 SRX11233337 GSM5402117 SRP325710 SRS9279455 GSM5402117 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402117 GSM5402117 GEO Accession GSM5402117 SRX11233338 GSM5402118 SRP325710 SRS9279458 GSM5402118 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402118 GSM5402118 GEO Accession GSM5402118 SRX11233339 GSM5402119 SRP325710 SRS9279457 GSM5402119 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402119 GSM5402119 GEO Accession GSM5402119 SRX11233340 GSM5402120 SRP325710 SRS9279459 GSM5402120 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402120 GSM5402120 GEO Accession GSM5402120 SRX11233341 GSM5402121 SRP325710 SRS9279460 GSM5402121 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402121 GSM5402121 GEO Accession GSM5402121 SRX11233342 GSM5402122 SRP325710 SRS9279461 GSM5402122 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402122 GSM5402122 GEO Accession GSM5402122 SRX11233343 GSM5402123 SRP325710 SRS9279462 GSM5402123 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402123 GSM5402123 GEO Accession GSM5402123 SRX11233344 GSM5402124 SRP325710 SRS9279464 GSM5402124 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402124 GSM5402124 GEO Accession GSM5402124 SRX11233345 GSM5402125 SRP325710 SRS9279463 GSM5402125 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402125 GSM5402125 GEO Accession GSM5402125 SRX11233346 GSM5402126 SRP325710 SRS9279465 GSM5402126 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402126 GSM5402126 GEO Accession GSM5402126 SRX11233347 GSM5402127 SRP325710 SRS9279466 GSM5402127 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402127 GSM5402127 GEO Accession GSM5402127 SRX11233348 GSM5402128 SRP325710 SRS9279467 GSM5402128 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402128 GSM5402128 GEO Accession GSM5402128 SRX11233349 GSM5402129 SRP325710 SRS9279468 GSM5402129 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402129 GSM5402129 GEO Accession GSM5402129 SRX11233350 GSM5402130 SRP325710 SRS9279469 GSM5402130 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402130 GSM5402130 GEO Accession GSM5402130 SRX11233351 GSM5402131 SRP325710 SRS9279470 GSM5402131 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402131 GSM5402131 GEO Accession GSM5402131 SRX11233352 GSM5402132 SRP325710 SRS9279472 GSM5402132 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402132 GSM5402132 GEO Accession GSM5402132 SRX11233353 GSM5402133 SRP325710 SRS9279471 GSM5402133 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402133 GSM5402133 GEO Accession GSM5402133 SRX11233354 GSM5402134 SRP325710 SRS9279473 GSM5402134 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402134 GSM5402134 GEO Accession GSM5402134 SRX11233355 GSM5402135 SRP325710 SRS9279474 GSM5402135 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402135 GSM5402135 GEO Accession GSM5402135 SRX11233356 GSM5402136 SRP325710 SRS9279475 GSM5402136 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402136 GSM5402136 GEO Accession GSM5402136 SRX11233357 GSM5402137 SRP325710 SRS9279476 GSM5402137 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402137 GSM5402137 GEO Accession GSM5402137 SRX11233358 GSM5402138 SRP325710 SRS9279477 GSM5402138 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402138 GSM5402138 GEO Accession GSM5402138 SRX11233359 GSM5402139 SRP325710 SRS9279479 GSM5402139 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402139 GSM5402139 GEO Accession GSM5402139 SRX11233360 GSM5402140 SRP325710 SRS9279478 GSM5402140 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402140 GSM5402140 GEO Accession GSM5402140 SRX11233361 GSM5402141 SRP325710 SRS9279480 GSM5402141 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402141 GSM5402141 GEO Accession GSM5402141 SRX11233362 GSM5402142 SRP325710 SRS9279481 GSM5402142 RNA-Seq TRANSCRIPTOMIC cDNA B cells from spleen and bone marrow of WT, CXCR4C1013G, Eµ-TCL1, and Eµ-TCL1;CXCR4C1013G were isolated with CD19 directed magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany). Only RNA samples with an RNA integrity number (RIN) > 7 were used for RNA-sequencing. RIN was determined using Agilent RNA 6000 Nano Kit (# 5067-1513, Agilent, Santa Clara, CA) and the Agilent 2100 Expert software (version B.02.10.SI764). Library preparation and single-end sequencing was subsequently performed by Novogene (UK) (Cambridge, United Kingdom) on a HiSeq2500 (Illumina, San Diego, CA) with a sequencing depth of more than 20 M reads/sample. RNA libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 gds 305402142 GSM5402142 GEO Accession GSM5402142