<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE179280" accession="SRP326508">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP326508</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA743052</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE179280</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>Gene expression analysis of HER2+ breast leptomeningeal carcinomatosis</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Transcriptome Analysis"/>
      <STUDY_ABSTRACT>Patient-derived primary HER2+ Leptomeningeal carcinomatosis (Lepto) cell lines were established. RNA-seq in various breast cancer cell lines were conducted to characterize the established cell lines. Gene expression analysis clearly indicated thatt Lepto cell lines are transcriptionally different from HER2 positive and negative metastatic breast cancer cell lines such as BT474 and MDA-MB-231 cells. Overall design: Gene expression comparison between HER2+ breast leptomeningeal carcinomatosis and other breast cancer subtypes</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE179280</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
    <STUDY_LINKS>
      <STUDY_LINK>
        <XREF_LINK>
          <DB>pubmed</DB>
          <ID>34247146</ID>
        </XREF_LINK>
      </STUDY_LINK>
    </STUDY_LINKS>
  </STUDY>
</STUDY_SET>
