SRP326661 PRJNA743296 GSE179333 Gene expression changes in REH following STAT3 pharmacological inhibition STAT3 (Signal transducer and activator of transcription 3) expression is associated with with t(12;21) acute lymphoblastic leukaemia (ALL) and it is crucial for the survival of the t(12;21) ALL . Our study investigated the STAT3 regulated pathways and discovered a novel STAT3-TP53 axis in B-ALL. In order to determine the STAT3 regulated pathways in t(12;21) ALL cells, we performed RNAseq analysis on the Pre-B Acute Lymphoblastic Leukemia (ALL) cell line REH, treated with DMSO vehicle control in comparison to 50uM S3I-021, a specific STAT3 inhibitor Overall design: Total cellular RNA was purified from DMSO and 50uM S3I-201 treated REH samples from three independent experiments GSE179333 pubmed 37794795