SRP326983 PRJNA743870 GSE179450 Transcriptome of miR-290-295 KO mESCs In order to identify direct microRNA targets in mouse embryonic stem cells (mESCs), we knocked out microRNA effector genes, profiled their transcriptomes and integrated the data with additional published OMICs data sets. To validate the analysis, we generated miR-290-295 KO mutant cell lines, assessed the transcriptome profile and compared the observed misregulation to the predictions of the analysis. Overall design: Transcriptome of miR-290-295 KO E14 mESCs were generated in biological duplicates using QuantSeq kit. GSE179450 pubmed 35899551