SRP327712 PRJNA744167 16S rRNA Sequecing Healthy and COVID-19 patients The development of SARS CoV 2 infection and the relative severity COVID 19 symptoms are due to different factors, where the microbiome seems to play a relevant role. In literature the possible relationships between the gut, lung, nasopharyngeal, or oral microbiome and COVID 19 have been investigated.Here, we analyzed the microbiota obtained from the sole nasal swabs of both positive and negative SARS CoV 2 individuals, in order to define possible differences in terms of bacterial composition in this niche of respiratory tract in relationship to patient's symptoms or features.