SRP328169 PRJNA746273 GSE180010 Copy number variation and expression of exportin-4 associates with severity of fibrosis in metabolic associated fatty liver disease A duplication in the exportin 4 (XPO4) CNV reduces the expression of hepatic XPO4 leading to maintaining sustained activation of SMAD3/SMAD4 and liver fibrosis. Overall design: We overexpressed Xpo4 in JS-1 cells with and without treatment of TGFß and undertook RNA-Seq analysis and compared to empty vector control GSE180010 pubmed 34388518