SRP328548 PRJNA747013 GSE180200 QPCTL deletion results in a rewiring of the tumor microenvironment [bulk RNA-seq] bulk RNA sequencing performed on the FACS sorted CD45-negative cells from QPCTL-proficient and -deficient TMEs; and, base-line comparison of lymphoid organs from QPCTL-KO and QPCTL-WT animals Overall design: The effects of QPCTL-deficiency were assessed in this study. To this end, a QPCTL-KO mouse strain was used. Mice homozygous for the QPCTL-KO allele or wild-type littermates were innoculated with either QPCTL-KO or QPCTL B16F10 tumor cells, respectively. After 14 days tumors were harvested, single cell suspensions were made and live CD45-negative cells were isolated by FACS, after which cells were processed for RNA sequencing. For baseline samples, whole organs were harvested from mice, snapfrozen and used for mRNA isolations. GSE180200 pubmed 35309731 parent_bioproject PRJNA747011