<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE185823" accession="SRP341200">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP341200</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA770963</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE185823</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>Interplay of vascular endothelial growth factor receptors in organ-specific endothelial cell survival</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Transcriptome Analysis"/>
      <STUDY_ABSTRACT>The aim was to study immediate changes in gene expression of lung and heart endothelial cells after single or compound deletions of vascular endothelial growth factors. Overall design: scRNA sequencing analysis of murine pulmonary and cardiac endothelial cells deleted of vascular endothelial growth factor receptors for 48 hours. Deletions include i) single deletions of Vegfr1, Vegfr2, and Vegfr3; ii) double deletions Vegfr1;Vegfr2 and Vegfr2;Vegfr3, and iii) triple deletion of Vegfr1;Vegfr2;Vegfr3. Naming of the files: a) C69, C72 etc indicates running number of experimental cohorts. R1=VEGFR1, R2=VEGFR2 and R3=VEGFR3. Ctrl samples are collected from tamoxifen treated littermate controls, Del samples had Cdh5-BAC-CreERT2. In each Ctrl and Del sample, equal amounts of sorted cells from 2-3 mice are pooled.</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE185823</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
    <STUDY_LINKS>
      <STUDY_LINK>
        <XREF_LINK>
          <DB>pubmed</DB>
          <ID>35050301</ID>
        </XREF_LINK>
      </STUDY_LINK>
    </STUDY_LINKS>
  </STUDY>
</STUDY_SET>
