SRX12694119 GSM5639810 SRP342176 SRS10644995 GSM5639810 RNA-Seq TRANSCRIPTOMIC cDNA Briefly, heart samples were mechanically minced into 1-mm3 pieces and digested in collagenase II (150 U mg/mL, Worthington, LS004174) followed by brief low-speed (850 rpm for 2 minutes) centrifugation to remove cardiomyocytes and tissue debris.Lin28S+/- cardiac interstitial cells were obtained by FACS sorting with Lin28 antibody and concurrent cell surface expression of Lin28/cKit The Chromium Single Cell 3' Library & Gel Bead Kit v3.1 (PN- 1000268), Chromium Single Cell 3' Chip G kit v2 (PN-1000120) and Dual Index Kit TT Set A, (PN-1000215) were used according to the manufacturers instructions in the Chromium Single Cell 3' Reagents Kits V3.1 User Guide. Illumina NovaSeq 6000 gds 305639810 GSM5639810 GEO Accession GSM5639810 SRX12694120 GSM5639808 SRP342176 SRS10644996 GSM5639808 RNA-Seq TRANSCRIPTOMIC cDNA Briefly, heart samples were mechanically minced into 1-mm3 pieces and digested in collagenase II (150 U mg/mL, Worthington, LS004174) followed by brief low-speed (850 rpm for 2 minutes) centrifugation to remove cardiomyocytes and tissue debris.Lin28S+/- cardiac interstitial cells were obtained by FACS sorting with Lin28 antibody and concurrent cell surface expression of Lin28/cKit The Chromium Single Cell 3' Library & Gel Bead Kit v3.1 (PN- 1000268), Chromium Single Cell 3' Chip G kit v2 (PN-1000120) and Dual Index Kit TT Set A, (PN-1000215) were used according to the manufacturers instructions in the Chromium Single Cell 3' Reagents Kits V3.1 User Guide. Illumina NovaSeq 6000 gds 305639808 GSM5639808 GEO Accession GSM5639808 SRX12694121 GSM5639809 SRP342176 SRS10644997 GSM5639809 RNA-Seq TRANSCRIPTOMIC cDNA Briefly, heart samples were mechanically minced into 1-mm3 pieces and digested in collagenase II (150 U mg/mL, Worthington, LS004174) followed by brief low-speed (850 rpm for 2 minutes) centrifugation to remove cardiomyocytes and tissue debris.Lin28S+/- cardiac interstitial cells were obtained by FACS sorting with Lin28 antibody and concurrent cell surface expression of Lin28/cKit The Chromium Single Cell 3' Library & Gel Bead Kit v3.1 (PN- 1000268), Chromium Single Cell 3' Chip G kit v2 (PN-1000120) and Dual Index Kit TT Set A, (PN-1000215) were used according to the manufacturers instructions in the Chromium Single Cell 3' Reagents Kits V3.1 User Guide. Illumina NovaSeq 6000 gds 305639809 GSM5639809 GEO Accession GSM5639809