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      <PRIMARY_ID>SRX12740008</PRIMARY_ID>
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    <TITLE>GSM5651253: mutant clpB replicate 1; Mus musculus; RNA-Seq</TITLE>
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        <PRIMARY_ID>SRP342720</PRIMARY_ID>
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          <PAIRED/>
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        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
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      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
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          <DB>gds</DB>
          <ID>305651253</ID>
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        <TAG>GEO Accession</TAG>
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  <EXPERIMENT alias="GSM5651254" accession="SRX12740009">
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      <PRIMARY_ID>SRX12740009</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651254</SUBMITTER_ID>
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    <TITLE>GSM5651254: mutant clpB replicate 2; Mus musculus; RNA-Seq</TITLE>
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      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
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          <PRIMARY_ID>SRS10688253</PRIMARY_ID>
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        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
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      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
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          <ID>305651254</ID>
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        <TAG>GEO Accession</TAG>
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  <EXPERIMENT alias="GSM5651255" accession="SRX12740010">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX12740010</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651255</SUBMITTER_ID>
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    <TITLE>GSM5651255: mutant clpB replicate 3; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
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      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688254">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688254</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM5651255</EXTERNAL_ID>
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      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
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    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
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          <DB>gds</DB>
          <ID>305651255</ID>
          <LABEL>GSM5651255</LABEL>
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        <TAG>GEO Accession</TAG>
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  <EXPERIMENT alias="GSM5651256" accession="SRX12740011">
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      <PRIMARY_ID>SRX12740011</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651256</SUBMITTER_ID>
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    <TITLE>GSM5651256: mutant clpB replicate 4; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
      </IDENTIFIERS>
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      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688255">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688255</PRIMARY_ID>
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      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
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        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
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      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
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          <DB>gds</DB>
          <ID>305651256</ID>
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        <TAG>GEO Accession</TAG>
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  <EXPERIMENT alias="GSM5651257" accession="SRX12740012">
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      <PRIMARY_ID>SRX12740012</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651257</SUBMITTER_ID>
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    <TITLE>GSM5651257: mutant gplX replicate 1; Mus musculus; RNA-Seq</TITLE>
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      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
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      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688256">
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          <PRIMARY_ID>SRS10688256</PRIMARY_ID>
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        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
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    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
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          <DB>gds</DB>
          <ID>305651257</ID>
          <LABEL>GSM5651257</LABEL>
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      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651257</VALUE>
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  <EXPERIMENT alias="GSM5651258" accession="SRX12740013">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX12740013</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651258</SUBMITTER_ID>
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    <TITLE>GSM5651258: mutant gplX replicate 2; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
      </IDENTIFIERS>
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    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688257">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688257</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM5651258</EXTERNAL_ID>
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      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
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      <EXPERIMENT_LINK>
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          <DB>gds</DB>
          <ID>305651258</ID>
          <LABEL>GSM5651258</LABEL>
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        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651258</VALUE>
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      <PRIMARY_ID>SRX12740014</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651259</SUBMITTER_ID>
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    <TITLE>GSM5651259: mutant gplX replicate 3; Mus musculus; RNA-Seq</TITLE>
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      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
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    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688258">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688258</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM5651259</EXTERNAL_ID>
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      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
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        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
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          <DB>gds</DB>
          <ID>305651259</ID>
          <LABEL>GSM5651259</LABEL>
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      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
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  <EXPERIMENT alias="GSM5651260" accession="SRX12740015">
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      <PRIMARY_ID>SRX12740015</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651260</SUBMITTER_ID>
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    <TITLE>GSM5651260: mutant gplX replicate 4; Mus musculus; RNA-Seq</TITLE>
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      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
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    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688259">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688259</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM5651260</EXTERNAL_ID>
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      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
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        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
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      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>305651260</ID>
          <LABEL>GSM5651260</LABEL>
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      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651260</VALUE>
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  <EXPERIMENT alias="GSM5651261" accession="SRX12740016">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX12740016</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651261</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM5651261: mutant lpcC replicate 1; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
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      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688260">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688260</PRIMARY_ID>
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      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
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    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
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      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>305651261</ID>
          <LABEL>GSM5651261</LABEL>
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      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651261</VALUE>
      </EXPERIMENT_ATTRIBUTE>
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  <EXPERIMENT alias="GSM5651262" accession="SRX12740017">
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      <PRIMARY_ID>SRX12740017</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651262</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM5651262: mutant lpcC replicate 2; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
      </IDENTIFIERS>
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    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688261">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688261</PRIMARY_ID>
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      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
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        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>305651262</ID>
          <LABEL>GSM5651262</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651262</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM5651263" accession="SRX12740018">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX12740018</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651263</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM5651263: mutant lpcC replicate 3; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688262">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688262</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM5651263</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>305651263</ID>
          <LABEL>GSM5651263</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651263</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM5651264" accession="SRX12740019">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX12740019</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651264</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM5651264: mutant lpcC replicate 4; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688263">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688263</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM5651264</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>305651264</ID>
          <LABEL>GSM5651264</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651264</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM5651265" accession="SRX12740020">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX12740020</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651265</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM5651265: Live vaccine Strain (LVS) replicate 1; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688264">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688264</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM5651265</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>305651265</ID>
          <LABEL>GSM5651265</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651265</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM5651266" accession="SRX12740021">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX12740021</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651266</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM5651266: Live vaccine Strain (LVS) replicate 2; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688265">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688265</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM5651266</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>305651266</ID>
          <LABEL>GSM5651266</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651266</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM5651267" accession="SRX12740022">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX12740022</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651267</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM5651267: Live vaccine Strain (LVS) replicate 3; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688266">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688266</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM5651267</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>305651267</ID>
          <LABEL>GSM5651267</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651267</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM5651268" accession="SRX12740023">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX12740023</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651268</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM5651268: Live vaccine Strain (LVS) replicate 4; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688267">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688267</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM5651268</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>305651268</ID>
          <LABEL>GSM5651268</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651268</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM5651269" accession="SRX12740024">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX12740024</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651269</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM5651269: Naïve replicate 1; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688268">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688268</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM5651269</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>305651269</ID>
          <LABEL>GSM5651269</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651269</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM5651270" accession="SRX12740025">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX12740025</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651270</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM5651270: Naïve replicate 2; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688269">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688269</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM5651270</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>305651270</ID>
          <LABEL>GSM5651270</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651270</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM5651271" accession="SRX12740026">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX12740026</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651271</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM5651271: Naïve replicate 3; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688270">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688270</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM5651271</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>305651271</ID>
          <LABEL>GSM5651271</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651271</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM5651272" accession="SRX12740027">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX12740027</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM5651272</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM5651272: Naïve replicate 4; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP342720" refname="GSE186408">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP342720</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS10688271">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS10688271</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM5651272</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from the spleens of mice vaccinated ID with LVS or one of the SCHU S4 deletion mutants ΔclpB, ΔgplX and ΔlpcC, (4 spleens from each group treated individually throughout) using Tri reagent (Life Technologies). Genomic DNA contamination was removed by Turbo DNA-Free Kit (Life Technologies). RNA was processed for paired-end RNA sequencing using Illumina Hi-Seq2000 (Genome Quebec). RNA-Seq Libraries were generated using the TruSeq strand RNA kit (Illumina). The RNA-Seq libraries were quantified by Qbit and qPCR according to the Illumina Sequencing Library qPCR Quantification Guide and the quality of the libraries was evaluated on Agilent Bioanalyzer 2100 using the Agilent DNA-100 chip.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>305651272</ID>
          <LABEL>GSM5651272</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM5651272</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
</EXPERIMENT_SET>
