SRP342811 PRJNA773931 PRJNA773517 Low-doses of sucralose alters fecal microbiota in high-fat diet induced obese rats Artificial sweeteners (AS) are widely used as sugar substitutes to reduce calorie intake. However, high doses of AS induced glucose tolerance by modulating gut microbiota. The objective of this study was to investigate the effects of lower doses of sucralose on fecal microbiota in obesity.