SRP343067 PRJNA769411 SARS-CoV-2 sequencing data collected from the New York City metropolitan area, vaccine breakthrough cases, May to August 2021 (Raw sequence reads) The Delta variant has become the predominant SARS-CoV-2 variant in the United States and worldwide. We describe clinical, demographic, and genomic features of SARS-CoV-2 breakthrough infections between May and August 2021 in a large multicenter healthcare institution in metropolitan New York. We performed unmatched and matched statistical analysis of variant distribution, and defined variant dynamics, their phylogenetic relatedness, and full spike protein mutation profiles. SARS-CoV-2 full genomes were obtained from 132 breakthrough cases after full vaccination with either BNT162b2 (Pfizer/BioNTech), mRNA-1273 (Moderna), or JNJ-78436735 (Janssen), and compared to 283 unvaccinated controls in the same period and cohort. SARS-CoV-2