SRX14014274 GSM5856776_r1 SRP357955 PRJNA802662 SRS11852088 GSM5856776 GSM5856776 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014275 GSM5856777_r1 SRP357955 PRJNA802662 SRS11852089 GSM5856777 GSM5856777 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014276 GSM5856778_r1 SRP357955 PRJNA802662 SRS11852090 GSM5856778 GSM5856778 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014277 GSM5856779_r1 SRP357955 PRJNA802662 SRS11852091 GSM5856779 GSM5856779 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014278 GSM5856780_r1 SRP357955 PRJNA802662 SRS11852092 GSM5856780 GSM5856780 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014279 GSM5856781_r1 SRP357955 PRJNA802662 SRS11852093 GSM5856781 GSM5856781 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014280 GSM5856782_r1 SRP357955 PRJNA802662 SRS11852094 GSM5856782 GSM5856782 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014281 GSM5856783_r1 SRP357955 PRJNA802662 SRS11852095 GSM5856783 GSM5856783 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014282 GSM5856784_r1 SRP357955 PRJNA802662 SRS11852096 GSM5856784 GSM5856784 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014283 GSM5856785_r1 SRP357955 PRJNA802662 SRS11852097 GSM5856785 GSM5856785 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014284 GSM5856786_r1 SRP357955 PRJNA802662 SRS11852098 GSM5856786 GSM5856786 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014285 GSM5856787_r1 SRP357955 PRJNA802662 SRS11852099 GSM5856787 GSM5856787 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014286 GSM5856788_r1 SRP357955 PRJNA802662 SRS11852100 GSM5856788 GSM5856788 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014287 GSM5856789_r1 SRP357955 PRJNA802662 SRS11852101 GSM5856789 GSM5856789 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014288 GSM5856790_r1 SRP357955 PRJNA802662 SRS11852102 GSM5856790 GSM5856790 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000 SRX14014289 GSM5856791_r1 SRP357955 PRJNA802662 SRS11852103 GSM5856791 GSM5856791 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from mouse tissues using TRIzol reagent (Life Technologies). Initially, 50-100 mg of fresh or snap-frozen tissue was placed in 2 mL tubes (Peqlab) together with ceramic beads (Mobio, Dianova GmbH) and 1 mL TRIzol. The tissue was homogenized using a Precellys 24 fast-prep machine (Bertin) at 5500 rpm for 2x 20 sec. Homogenates were then transferred to a new tube and it proceeded with the addition of chloroform and subsequent phase separation according to the manufacturer's instruction. The RNA pellet was resuspended in RNase/DNase free H2O (Gibco). RNA isolation for RNAseq was performed using the 'Direct-zol RNA MiniPrep Kit' (Zymo Research) according to the manufacturer's instruction. Purified RNA was submitted to the Cologne Centre for Genomics for further processing. Libraries were prepared using the 'TruSeq mRNA Stranded Sample Preparation Kit' (Illumina) and validated on a tape station (Agilent). Equimolar amounts of libraries were pooled, quantified (Peqlab KAPA Library Quantification Kit, Applied Biosystems 7900HT Sequence Detection System) and finally sequenced on a 'NovaSeq 6000 sequencer' (Illumina). Illumina NovaSeq 6000