SRP372449 PRJNA832568 GSE201655 An activity-specificity trade-off encoded in human transcription factors Transcription factors play essential roles in cell type specification during differentiation, and small sets of transcription factors can reprogram cell identity. Therefore, we tested the impact of increasing periodicity of aromatic residues on the ability of transcription factors to reprogram cells. Overall design: We performed multiple RNAseq, scRNAseq, TTSlamSeq, and ChIPseq of the cells expressing the WT, "AroLITE" and "AroPERFECT" of CEBPa, HOXD4, NGN2, and MYOD1 proteins after transgene induction to measure differentiation of specific cell lines. GSE201655 pubmed 38969762