<?xml version="1.0" encoding="UTF-8"?>
<EXPERIMENT_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <EXPERIMENT accession="SRX15038526" alias="GSM6070958_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038526</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070958_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070958: mammary gland tissue, age 12M, no Esr1 transgene induction, biol rep 1 [CERM012M_4162-CERM_S6]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785378">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785378</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070958</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070958</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038527" alias="GSM6070959_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038527</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070959_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070959: mammary gland tissue, age 12M, no Esr1 transgene induction, biol rep 2 [CERM012M_4170II-CERM_S8]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785379">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785379</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070959</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070959</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038528" alias="GSM6070960_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038528</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070960_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070960: mammary gland tissue, age 12M, no Esr1 transgene induction, biol rep 3 [CERM012M_4171a-CERM_S7]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785380">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785380</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070960</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070960</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038529" alias="GSM6070961_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038529</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070961_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070961: mammary gland tissue, age 12M, 1 week Esr1 transgene induction, biol rep 1 [CERM1WDoxy12M_4098IIb-CERM_S3]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785381">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785381</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070961</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070961</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038530" alias="GSM6070962_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038530</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070962_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070962: mammary gland tissue, age 12M, 1 week Esr1 transgene induction, biol rep 2 [CERM1WDoxy12M_4099-CERM_S5]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785382">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785382</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070962</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070962</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038531" alias="GSM6070963_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038531</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070963_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070963: mammary gland tissue, age 12M, 1 week Esr1 transgene induction, biol rep 3 [CERM1WDoxy12M_4107-CERM_S4]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785383">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785383</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070963</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070963</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038532" alias="GSM6070964_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038532</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070964_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070964: mammary gland tissue, age 18M, no Esr1 transgene induction, biol rep 1 [CERM018M_4226-CERM_S2]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785384">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785384</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070964</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070964</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038533" alias="GSM6070965_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038533</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070965_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070965: mammary gland tissue, age 18M, no Esr1 transgene induction, biol rep 2 [CERM018M_4235-CERM_S1]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785385">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785385</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070965</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070965</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038534" alias="GSM6070966_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038534</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070966_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070966: mammary gland tissue, age 18M, no Esr1 transgene induction, biol rep 3 [CERM018M_4312-CERM_S7]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785386">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785386</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070966</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070966</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038535" alias="GSM6070967_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038535</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070967_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070967: mammary gland tissue, age 18M, 1 week Esr1 transgene induction, biol rep 1 [CERM1WDoxy18M_4219-CERM_S6]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785387">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785387</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070967</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070967</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038536" alias="GSM6070968_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038536</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070968_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070968: mammary gland tissue, age 18M, 1 week Esr1 transgene induction, biol rep 2 [CERM1WDoxy18M_4222-CERM_S8]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785388">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785388</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070968</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070968</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038537" alias="GSM6070969_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038537</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070969_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070969: mammary gland tissue, age 18M, 1 week Esr1 transgene induction, biol rep 3 [CERM1WDoxy18M_4223-CERM_S1]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785389">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785389</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070969</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070969</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038538" alias="GSM6070970_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038538</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070970_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070970: mammary gland tissue, age 24M, no Esr1 transgene induction, biol rep 1 [4942CERM0-24M_S1]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785390">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785390</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070970</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070970</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038539" alias="GSM6070971_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038539</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070971_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070971: mammary gland tissue, age 24M, no Esr1 transgene induction, biol rep 2 [4892CERM24M0D_S1]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785391">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785391</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070971</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070971</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038540" alias="GSM6070972_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038540</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070972_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070972: mammary gland tissue, age 24M, no Esr1 transgene induction, biol rep 3 [4925CERM24M0D_S4]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785392">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785392</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070972</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070972</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038541" alias="GSM6070973_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038541</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070973_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070973: mammary gland tissue, age 24M, 6 months Esr1 transgene induction, biol rep 1 [4709CERM6m24M_S2]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785393">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785393</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070973</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070973</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038542" alias="GSM6070974_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038542</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070974_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070974: mammary gland tissue, age 24M, 6 months Esr1 transgene induction, biol rep 2 [4641CERM6M24M_S2]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785394">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785394</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070974</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070974</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038543" alias="GSM6070975_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038543</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070975_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070975: mammary gland tissue, age 24M, 6 months Esr1 transgene induction, biol rep 3 [1702CERM6M24M_S2]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785395">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785395</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070975</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070975</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038544" alias="GSM6070976_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038544</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070976_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070976: mammary gland tissue, age 24M, 12 months Esr1 transgene induction, biol rep 1 [4816CERM12M24M_S3]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785396">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785396</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070976</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070976</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038545" alias="GSM6070977_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038545</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070977_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070977: mammary gland tissue, age 24M, 12 months Esr1 transgene induction, biol rep 2 [4754CERM12M24M_S3]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785397">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785397</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070977</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070977</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038546" alias="GSM6070978_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038546</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070978_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070978: mammary gland tissue, age 24M, 12 months Esr1 transgene induction, biol rep 3 [4728CERM12M24M_S3]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785398">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785398</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070978</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070978</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038547" alias="GSM6070979_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038547</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070979_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070979: mammary gland tissue, age 30M, 18 months Esr1 transgene induction, biol rep 1 [4607CERM30m18M_S1]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785399">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785399</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070979</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070979</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038548" alias="GSM6070980_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038548</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070980_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070980: mammary gland tissue, age 30M, 18 months Esr1 transgene induction, biol rep 2 [4629CERM18M30M_S4]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785400">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785400</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070980</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070980</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038549" alias="GSM6070981_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038549</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070981_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070981: mammary gland tissue, age 30M, 18 months Esr1 transgene induction, biol rep 3 [4550CERM18M30M_S4 ]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785401">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785401</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070981</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070981</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038550" alias="GSM6070982_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038550</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070982_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070982: mammary gland tissue, age 12M, no CYP19A1 transgene induction, biol rep 1 [AROM012M_3848b-AROM_S6]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785402">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785402</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070982</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070982</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038551" alias="GSM6070983_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038551</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070983_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070983: mammary gland tissue, age 12M, no CYP19A1 transgene induction, biol rep 2 [AROM012M_3865-AROM_S7]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785403">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785403</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070983</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070983</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038552" alias="GSM6070984_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038552</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070984_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070984: mammary gland tissue, age 12M, no CYP19A1 transgene induction, biol rep 3 [AROM012M_3866-AROM_S2]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785404">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785404</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070984</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070984</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038553" alias="GSM6070985_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038553</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070985_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070985: mammary gland tissue, age 12M, 1 week CYP19A1 transgene induction, biol rep 1 [AROM1WDoxy12M_3820-AR0M_S3]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785405">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785405</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070985</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070985</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038554" alias="GSM6070986_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038554</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070986_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070986: mammary gland tissue, age 12M, 1 week CYP19A1 transgene induction, biol rep 2 [AROM1WDoxy12M_3826-AROM_S8]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785406">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785406</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070986</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070986</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038555" alias="GSM6070987_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038555</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070987_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070987: mammary gland tissue, age 12M, 1 week CYP19A1 transgene induction, biol rep 3 [AROM1WDoxy12M_3829-AROM_S4]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785407">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785407</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070987</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070987</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038556" alias="GSM6070988_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038556</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070988_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070988: mammary gland tissue, age 18M, no CYP19A1 transgene induction, biol rep 1 [AROM018M_3735-AROM_S5]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785408">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785408</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070988</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070988</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038557" alias="GSM6070989_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038557</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070989_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070989: mammary gland tissue, age 18M, no CYP19A1 transgene induction, biol rep 2 [AROM018M_3872-AROM_S1]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785409">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785409</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070989</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070989</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038558" alias="GSM6070990_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038558</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070990_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070990: mammary gland tissue, age 18M, no CYP19A1 transgene induction, biol rep 3 [AROM018M_3885-AROM_S5]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785410">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785410</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070990</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070990</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038559" alias="GSM6070991_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038559</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070991_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070991: mammary gland tissue, age 18M, 1 week CYP19A1 transgene induction, biol rep 1 [AROM1WDoxy18M_3674-AROM_S2]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785411">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785411</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070991</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070991</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038560" alias="GSM6070992_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038560</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070992_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070992: mammary gland tissue, age 18M, 1 week CYP19A1 transgene induction, biol rep 2 [AROM1WDoxy18M_3678-AROM_S3]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785412">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785412</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070992</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070992</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038561" alias="GSM6070993_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038561</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070993_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070993: mammary gland tissue, age 18M, 1 week CYP19A1 transgene induction, biol rep 3 [AROM1WDoxy18M_3722-AROM_S4]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785413">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785413</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070993</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070993</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038562" alias="GSM6070994_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038562</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070994_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070994: mammary gland tissue, age 24M, no CYP19A1 transgene induction, biol rep 1 [4409AROM24M0D_S5]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785414">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785414</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070994</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070994</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038563" alias="GSM6070995_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038563</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070995_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070995: mammary gland tissue, age 24M, no CYP19A1 transgene induction, biol rep 2 [4403AROM24M0D_S5]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785415">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785415</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070995</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070995</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038564" alias="GSM6070996_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038564</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070996_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070996: mammary gland tissue, age 24M, no CYP19A1 transgene induction, biol rep 3 [4388AROM24M0D_S5]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785416">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785416</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070996</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070996</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038565" alias="GSM6070997_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038565</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070997_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070997: mammary gland tissue, age 24M, 6 months CYP19A1 transgene induction, biol rep 1 [4200AROM6M24M_S6]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785417">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785417</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070997</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070997</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038566" alias="GSM6070998_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038566</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070998_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070998: mammary gland tissue, age 24M, 6 months CYP19A1 transgene induction, biol rep 2 [4212AROM6M24M_S6]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785418">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785418</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070998</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070998</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038567" alias="GSM6070999_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038567</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6070999_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6070999: mammary gland tissue, age 24M, 6 months CYP19A1 transgene induction, biol rep 3 [4230AROM6M24M_S6]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785419">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785419</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6070999</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6070999</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038568" alias="GSM6071000_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038568</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6071000_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6071000: mammary gland tissue, age 24M, 12 months CYP19A1 transgene induction, biol rep 1 [4321AROM24M12M_S7]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785420">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785420</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6071000</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6071000</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038569" alias="GSM6071001_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038569</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6071001_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6071001: mammary gland tissue, age 24M, 12 months CYP19A1 transgene induction, biol rep 2 [4370AROM24M12M_S7]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785421">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785421</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6071001</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6071001</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038570" alias="GSM6071002_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038570</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6071002_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6071002: mammary gland tissue, age 24M, 12 months CYP19A1 transgene induction, biol rep 3 [4379AROM12M24M_S7]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785422">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785422</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6071002</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6071002</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038571" alias="GSM6071003_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038571</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6071003_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6071003: mammary gland tissue, age 30M, 18 months CYP19A1 transgene induction, biol rep 1 [4182AROM18M30M_S8]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785423">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785423</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6071003</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6071003</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038572" alias="GSM6071004_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038572</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6071004_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6071004: mammary gland tissue, age 30M, 18 months CYP19A1 transgene induction, biol rep 2 [4171AROM18M30M_S8]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785424">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785424</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6071004</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6071004</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15038573" alias="GSM6071005_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15038573</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6071005_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6071005: mammary gland tissue, age 30M, 18 months CYP19A1 transgene induction, biol rep 3 [4107AROM18M30M_S8]; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP372661">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP372661</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA832964</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12785425">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12785425</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6071005</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6071005</LIBRARY_NAME>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Thoracic (second) mammary glands were flash frozen in liquid nitrogen and stored at -80℃ until processing. Glands were thawed in Invitrogen Trizol reagent (ThermoFisher Scientific) and homogenized using a Qiagen Tissuruptor and Qiashredder (Qiagen). RNA was then isolated using Direct Zol RNA miniprep kit (Zymo Research), quantified on a Qubit 2.0 or 4.0 Fluorometer (Qiagen) and analyzed for RNA integrity using the Agilent 2100 Bioanalyzer. Indexed, single-index sequencing libraries prepared from total RNA (1 microgram/sample) using the Illumina TruSeq Stranded Total RNA Library Preparation Human/Mouse/Rat Kit (rRNA depletion and random-primed cDNA synthesis) Sequencing using the Illumina NextSeq 550, SE 75 bp read length; minimum reads ≥50M per sample</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 550</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
</EXPERIMENT_SET>
