SRX15039991 GSM6071753_r1 SRP372714 PRJNA833076 SRS12786600 GSM6071753 GSM6071753 ChIP-Seq GENOMIC ChIP Fixed cells were lysed with glass-beads in Biospec Mini-Beadbeater 16, DNA was sheared by sonication to ~ 250 bp fragments, cleared by centrifugation at 3,000 g and immunoprecipitated with 2ug of MYC antibody (sc40, Santa Cruz Biotechnology). Immunoprecipitated DNA was recovered by incubation with protein G slurry and the crosslink reversed at 65˚C. Input and immunoprecipitated DNA was treated with RNase A (5ug) and Protease K (40ug) and column purified by Qiaquick PCR purification kit (Qiagen). Sequencing libraries were constructed from ~1 ng of input or immunoprecipitated DNA using NextUltra II DNA Library Prep (New England Biolabs) according to the manufacturer's instructions. Libraries were purified with AMPure XP magnetic beads (Beckman Coulter) and analyzed on Bioanalyzer 2100 (Agilent) prior to sequencing using the NextSeq 500 sequencer (Illumina). NextSeq 500 SRX15039992 GSM6071754_r1 SRP372714 PRJNA833076 SRS12786601 GSM6071754 GSM6071754 ChIP-Seq GENOMIC ChIP Fixed cells were lysed with glass-beads in Biospec Mini-Beadbeater 16, DNA was sheared by sonication to ~ 250 bp fragments, cleared by centrifugation at 3,000 g and immunoprecipitated with 2ug of MYC antibody (sc40, Santa Cruz Biotechnology). Immunoprecipitated DNA was recovered by incubation with protein G slurry and the crosslink reversed at 65˚C. Input and immunoprecipitated DNA was treated with RNase A (5ug) and Protease K (40ug) and column purified by Qiaquick PCR purification kit (Qiagen). Sequencing libraries were constructed from ~1 ng of input or immunoprecipitated DNA using NextUltra II DNA Library Prep (New England Biolabs) according to the manufacturer's instructions. Libraries were purified with AMPure XP magnetic beads (Beckman Coulter) and analyzed on Bioanalyzer 2100 (Agilent) prior to sequencing using the NextSeq 500 sequencer (Illumina). NextSeq 500